EMDB-17297: Structure of a human 48S translation initiation complex with eIF4...

基本情報

登録情報

データベース: EMDB / ID: EMD-17297

• タイトル: Structure of a human 48S translation initiation complex with eIF4F and eIF4A
• マップデータ: Human 48S complex

試料

• 複合体: Human 48S translation initiation complex
  • タンパク質・ペプチド: x 53種
  • RNA: x 3種
• リガンド: x 2種

• キーワード: translation / eIF4A / eIF4F / initiation / ribosome / mRNA

機能・相同性

分子機能:

positive regulation of eukaryotic translation initiation factor 4F complex assembly / male germ cell proliferation / eukaryotic initiation factor eIF2 binding / positive regulation of translation in response to endoplasmic reticulum stress / translation initiation ternary complex / regulation of translation in response to endoplasmic reticulum stress / glial limiting end-foot / HRI-mediated signaling / response to manganese-induced endoplasmic reticulum stress / Cellular response to mitochondrial stress / viral translational termination-reinitiation / positive regulation of type B pancreatic cell apoptotic process / Response of EIF2AK1 (HRI) to heme deficiency / Recycling of eIF2:GDP / methionyl-initiator methionine tRNA binding / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / negative regulation of translational initiation in response to stress / eukaryotic translation initiation factor 3 complex, eIF3e / PERK-mediated unfolded protein response / cap-dependent translational initiation / eukaryotic initiation factor 4E binding / eukaryotic translation initiation factor 3 complex, eIF3m / PERK regulates gene expression / response to kainic acid / IRES-dependent viral translational initiation / translation reinitiation / eukaryotic translation initiation factor 2 complex / RNA cap binding / eukaryotic translation initiation factor 4F complex / nuclear stress granule / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / formation of cytoplasmic translation initiation complex / regulation of cellular response to stress / multi-eIF complex / regulation of translational initiation in response to stress / eukaryotic translation initiation factor 3 complex / eukaryotic 43S preinitiation complex / translation factor activity, RNA binding / mRNA cap binding / Deadenylation of mRNA / formation of translation preinitiation complex / miRNA-mediated gene silencing by inhibition of translation / eukaryotic 48S preinitiation complex / M-decay: degradation of maternal mRNAs by maternally stored factors / negative regulation of endoplasmic reticulum unfolded protein response / oxidized pyrimidine DNA binding / response to TNF agonist / positive regulation of base-excision repair / positive regulation of ubiquitin-protein transferase activity / positive regulation of respiratory burst involved in inflammatory response / regulation of translational initiation / positive regulation of gastrulation / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage / protein tyrosine kinase inhibitor activity / protein-synthesizing GTPase / IRE1-RACK1-PP2A complex / positive regulation of Golgi to plasma membrane protein transport / nucleolus organization / positive regulation of DNA-templated transcription initiation / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / TNFR1-mediated ceramide production / GDP-dissociation inhibitor activity / negative regulation of RNA splicing / positive regulation of protein localization to cell periphery / neural crest cell differentiation / supercoiled DNA binding / metal-dependent deubiquitinase activity / NF-kappaB complex / negative regulation of DNA repair / cytoplasmic translational initiation / oxidized purine DNA binding / cysteine-type endopeptidase activator activity involved in apoptotic process / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / rRNA modification in the nucleus and cytosol / negative regulation of bicellular tight junction assembly / ubiquitin-like protein conjugating enzyme binding / regulation of establishment of cell polarity / negative regulation of phagocytosis / erythrocyte homeostasis / cytoplasmic side of rough endoplasmic reticulum membrane / Formation of the ternary complex, and subsequently, the 43S complex / ion channel inhibitor activity / laminin receptor activity / protein kinase A binding / pigmentation / Ribosomal scanning and start codon recognition / positive regulation of mitochondrial depolarization / Translation initiation complex formation / positive regulation of protein metabolic process / negative regulation of Wnt signaling pathway / fibroblast growth factor binding / monocyte chemotaxis / BH3 domain binding / Protein hydroxylation / negative regulation of translational frameshifting / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / TOR signaling / positive regulation of GTPase activity / SARS-CoV-1 modulates host translation machinery / mTORC1-mediated signalling

ドメイン・相同性:

ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain / EIF3I / Eukaryotic translation initiation factor 3 subunit G / Eukaryotic translation initiation factor 3 subunit G, N-terminal / eIF3G, RNA recognition motif / Eukaryotic translation initiation factor 3 subunit G / Eukaryotic translation initiation factor 3 subunit I / Eukaryotic translation initiation factor 3 subunit D / Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) / Eukaryotic translation initiation factor 3 subunit H / eIF3h, C-terminal / C-terminal region of eIF3h / Eukaryotic translation initiation factor 3 subunit B / eIF3B, RNA recognition motif / Eukaryotic translation initiation factor 3 subunit F / Translation initiation factor, beta propellor-like domain / Translation initiation factor 3 complex subunit L / RNA polymerase I-associated factor PAF67 / Eukaryotic translation initiation factor 3 subunit M / eIF3 subunit M, C-terminal helix domain / : / Eukaryotic translation initiation factor eIF2A / eIF3 subunit 6 N terminal domain / eIF3 subunit M, C-terminal helix / Eukaryotic translation initiation factor 3 subunit E, C-terminal / EIF3CL-like, C-terminal domain / Eukaryotic translation initiation factor 3 subunit E / Eukaryotic translation initiation factor 3 subunit E, N-terminal / eIF3 subunit 6 N terminal domain / Eukaryotic translation initiation factor 3 subunit K / Translation initiation factor 3, subunit 12, N-terminal, eukaryotic / : / eIF3a, PCI domain, TPR-like region / Eukaryotic translation initiation factor 3 subunit A / Eukaryotic translation initiation factor 3 subunit C, N-terminal domain / Eukaryotic translation initiation factor 3 subunit C / Eukaryotic translation initiation factor 3 subunit 8 N-terminus / Translation initiation factor IF2/IF5 domain / Translation initiation factor IF2/IF5, N-terminal / Translation initiation factor IF2/IF5, zinc-binding / Translation initiation factor IF2/IF5 / Domain found in IF2B/IF5 / domain present in translation initiation factor eIF2B and eIF5 / eIF4-gamma/eIF5/eIF2-epsilon / Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 / W2 domain / W2 domain profile. / Translation initiation factor 1A (eIF-1A), conserved site / Eukaryotic initiation factor 1A signature. / Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 / eukaryotic translation initiation factor 1A / Translation initiation factor 1A (eIF-1A) / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / MIF4G domain / Initiation factor eIF2 gamma, C-terminal / Initiation factor eIF2 gamma, domain 2 / Initiation factor eIF2 gamma, GTP-binding domain / Initiation factor eIF2 gamma, C terminal / Translation initiation factor 2, alpha subunit / Translation initiation factor 2, alpha subunit, middle domain superfamily / Translation initiation factor 2, alpha subunit, C-terminal / IF2a, S1-like domain / Eukaryotic translation initiation factor 2 alpha subunit / : / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3 / RNA-binding domain, S1, IF1 type / Translation initiation factor 1A / IF-1 / S1 domain IF1 type profile. / DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / CSN8/PSMD8/EIF3K / CSN8/PSMD8/EIF3K family / DEAD-box RNA helicase Q motif profile. / Rpn11/EIF3F, C-terminal / Maintenance of mitochondrial structure and function / : / motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 / PCI domain / Proteasome component (PCI) domain / PCI domain profile. / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / 40S ribosomal protein SA / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Ubiquitin-like protein FUBI / JAB1/Mov34/MPN/PAD-1 ubiquitin protease / S1 domain profile. / : / Ribosomal protein S26e signature. / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S21e, conserved site / Ribosomal protein S21e signature. / : / Ribosomal protein S12e signature.

構成要素:

Eukaryotic translation initiation factor 3 subunit F / Eukaryotic translation initiation factor 3 subunit D / Eukaryotic translation initiation factor 3 subunit H / Eukaryotic translation initiation factor 3 subunit G / Eukaryotic translation initiation factor 2 subunit 1 / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Eukaryotic translation initiation factor 2 subunit 2 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 / Small ribosomal subunit protein eS19 / Eukaryotic translation initiation factor 2 subunit 3 / Small ribosomal subunit protein eS27 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein eS10 / Eukaryotic translation initiation factor 1A, X-chromosomal / Eukaryotic translation initiation factor 5 / Eukaryotic translation initiation factor 3 subunit B / Eukaryotic translation initiation factor 3 subunit E / Eukaryotic initiation factor 4A-I / Small ribosomal subunit protein uS10 / Small ribosomal subunit protein eS1 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS11 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS13 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein eS4, X isoform / Small ribosomal subunit protein eS6 / Small ribosomal subunit protein uS19 / Small ribosomal subunit protein eS24 / Small ribosomal subunit protein eS25 / Small ribosomal subunit protein eS26 / Small ribosomal subunit protein eS28 / Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / Small ribosomal subunit protein eS32 / Ubiquitin-ribosomal protein eS31 fusion protein / Small ribosomal subunit protein eS21 / Small ribosomal subunit protein RACK1 / Eukaryotic translation initiation factor 4 gamma 1 / Eukaryotic translation initiation factor 3 subunit I / Eukaryotic translation initiation factor 3 subunit A / Eukaryotic translation initiation factor 3 subunit M / Eukaryotic translation initiation factor 3 subunit C / Eukaryotic translation initiation factor 3 subunit K / Eukaryotic translation initiation factor 3 subunit L

• 生物種: Homo sapiens (ヒト)
• 手法: 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.5 Å
• データ登録者: Brito Querido J / Sokabe M / Diaz-Lopez I / Gordiyenko Y / Fraser CS / Ramakrishnan V

資金援助

英国, 米国, 3件

Organization	Grant number	国
UK Research and Innovation (UKRI)	MC_U105184332	英国
Wellcome Trust	WT096570	英国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)	GM092927	米国

• 引用: ジャーナル: Nat Struct Mol Biol / 年: 2024; タイトル: The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.; 著者: Jailson Brito Querido / Masaaki Sokabe / Irene Díaz-López / Yuliya Gordiyenko / Christopher S Fraser / V Ramakrishnan / ; 要旨: Eukaryotic translation initiation involves recruitment of the 43S pre-initiation complex to the 5' end of mRNA by the cap-binding complex eIF4F, forming the 48S translation initiation complex (48S), which then scans along the mRNA until the start codon is recognized. We have previously shown that eIF4F binds near the mRNA exit channel of the 43S, leaving open the question of how mRNA secondary structure is removed as it enters the mRNA channel on the other side of the 40S subunit. Here we report the structure of a human 48S that shows that, in addition to the eIF4A that is part of eIF4F, there is a second eIF4A helicase bound at the mRNA entry site, which could unwind RNA secondary structures as they enter the 48S. The structure also reveals conserved interactions between eIF4F and the 43S, probaby explaining how eIF4F can promote mRNA recruitment in all eukaryotes.

履歴

登録	2023年5月6日	-
ヘッダ(付随情報) 公開	2024年2月7日	-
マップ公開	2024年2月7日	-
更新	2024年4月24日	-
現状	2024年4月24日	処理サイト: PDBe / 状態: 公開

マップ

• ファイル: ダウンロード / ファイル: emd_17297.map.gz / 形式: CCP4 / 大きさ: 244.1 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• 注釈: Human 48S complex
• ボクセルのサイズ: X=Y=Z: 1.06 Å

密度

表面レベル	登録者による: 0.006
最小 - 最大	-0.023388347 - 0.0645033
平均 (標準偏差)	0.0003936971 (±0.0022750173)

• 対称性: 空間群: 1

詳細

EMDB XML:

マップ形状	Axis order X Y Z Origin 0 0 0 サイズ 400 400 400 Spacing 400 400 400
セル	A=B=C: 423.99997 Å α=β=γ: 90.0 °

添付データ

マスク #1

• ファイル: emd_17297_msk_1.map

追加マップ: Body1 - 3D multi-body refinement of 48S

• ファイル: emd_17297_additional_1.map
• 注釈: Body1 - 3D multi-body refinement of 48S

追加マップ: eIF3 after focus 4F

• ファイル: emd_17297_additional_10.map
• 注釈: eIF3_after_focus_4F

追加マップ: PIC after focus EntrySite

• ファイル: emd_17297_additional_11.map
• 注釈: PIC_after_focus_EntrySite

追加マップ: Body2 - 3D multi-body refinement of 48S

• ファイル: emd_17297_additional_2.map
• 注釈: Body2 - 3D multi-body refinement of 48S

追加マップ: Body3 - 3D multi-body refinement of 48S

• ファイル: emd_17297_additional_3.map
• 注釈: Body3 - 3D multi-body refinement of 48S

追加マップ: PIC after focus EntrySite Resampled map

• ファイル: emd_17297_additional_4.map
• 注釈: PIC_after_focus_EntrySite Resampled map

追加マップ: eIF4F-eIF3 after focus EntrySite Resampled map

• ファイル: emd_17297_additional_5.map
• 注釈: eIF4F-eIF3_after_focus_EntrySite Resampled map

追加マップ: eIF3 after focus 4F Resampled map

• ファイル: emd_17297_additional_6.map
• 注釈: eIF3_after_focus_4F Resampled map

追加マップ: eIF4F after focus 4F Resampled map

• ファイル: emd_17297_additional_7.map
• 注釈: eIF4F_after_focus_4F Resampled map

追加マップ: eIF4F eIF3 after focus 4F

• ファイル: emd_17297_additional_8.map
• 注釈: eIF4F_eIF3 after_focus_4F

追加マップ: eIF4F after focus 4F

• ファイル: emd_17297_additional_9.map
• 注釈: eIF4F_after_focus_4F

ハーフマップ: Half map1 48S

• ファイル: emd_17297_half_map_1.map
• 注釈: Half map1 48S

ハーフマップ: Half map1 48S

• ファイル: emd_17297_half_map_2.map
• 注釈: Half map1 48S

試料の構成要素

全体 : Human 48S translation initiation complex

• 全体: 名称: Human 48S translation initiation complex

要素

• 複合体: Human 48S translation initiation complex
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit E
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit F
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit G
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit H
  • タンパク質・ペプチド: 60S ribosomal protein L41
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit A
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit K
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit M
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 2 subunit 1
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 2 subunit 3
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit I
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 1A, X-chromosomal
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 5
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit B
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit C
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit L
  • タンパク質・ペプチド: 40S ribosomal protein S7
  • タンパク質・ペプチド: 40S ribosomal protein S27
  • タンパク質・ペプチド: 40S ribosomal protein S21
  • タンパク質・ペプチド: 40S ribosomal protein S2
  • タンパク質・ペプチド: 40S ribosomal protein S3a
  • タンパク質・ペプチド: 40S ribosomal protein SA
  • タンパク質・ペプチド: 40S ribosomal protein S26
  • タンパク質・ペプチド: 40S ribosomal protein S6
  • タンパク質・ペプチド: 40S ribosomal protein S14
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 2 subunit 2
  • タンパク質・ペプチド: 40S ribosomal protein S13
  • RNA: 18S rRNA
  • タンパク質・ペプチド: 40S ribosomal protein S11
  • タンパク質・ペプチド: 40S ribosomal protein S4, X isoform
  • タンパク質・ペプチド: 40S ribosomal protein S9
  • タンパク質・ペプチド: 40S ribosomal protein S23
  • タンパク質・ペプチド: 40S ribosomal protein S30
  • タンパク質・ペプチド: 40S ribosomal protein S15a
  • タンパク質・ペプチド: 40S ribosomal protein S8
  • タンパク質・ペプチド: 40S ribosomal protein S24
  • タンパク質・ペプチド: 40S ribosomal protein S5
  • タンパク質・ペプチド: 40S ribosomal protein S16
  • タンパク質・ペプチド: 40S ribosomal protein S3
  • タンパク質・ペプチド: 40S ribosomal protein S10
  • タンパク質・ペプチド: 40S ribosomal protein S15
  • タンパク質・ペプチド: Receptor of activated protein C kinase 1
  • タンパク質・ペプチド: 40S ribosomal protein S19
  • タンパク質・ペプチド: 40S ribosomal protein S25
  • タンパク質・ペプチド: Small ribosomal subunit protein uS13
  • タンパク質・ペプチド: 40S ribosomal protein S29
  • タンパク質・ペプチド: Ubiquitin-40S ribosomal protein S27a
  • タンパク質・ペプチド: 40S ribosomal protein S12
  • タンパク質・ペプチド: 40S ribosomal protein S28
  • タンパク質・ペプチド: 40S ribosomal protein S17
  • タンパク質・ペプチド: 40S ribosomal protein S20
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 3 subunit D
  • RNA: tRNAiMet
  • RNA: mRNA
  • タンパク質・ペプチド: Eukaryotic initiation factor 4A-I
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 4 gamma 1
• リガンド: ZINC ION
• リガンド: MAGNESIUM ION

超分子 #1: Human 48S translation initiation complex

• 超分子: 名称: Human 48S translation initiation complex / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1-#56
• 由来(天然): 生物種: Homo sapiens (ヒト)

分子 #1: Eukaryotic translation initiation factor 3 subunit E

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit E; タイプ: protein_or_peptide / ID: 1 ; 詳細: Eukaryotic translation initiation factor 3 subunit E; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 52.281633 KDa
• 組換発現: 生物種: Homo sapiens (ヒト)

配列

文字列:

MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN LYSDDIPHAL REKRTTVVAQ LKQLQAETE PIVKMFEDPE TTRQMQSTRD GRMLFDYLAD KHGFRQEYLD TLYRYAKFQY ECGNYSGAAE YLYFFRVLVP A TDRNALSS LWGKLASEIL MQNWDAAMED LTRLKETIDN NSVSSPLQSL QQRTWLIHWS LFVFFNHPKG RDNIIDLFLY QP QYLNAIQ TMCPHILRYL TTAVITNKDV RKRRQVLKDL VKVIQQESYT YKDPITEFVE CLYVNFDFDG AQKKLRECES VLV NDFFLV ACLEDFIENA RLFIFETFCR IHQCISINML ADKLNMTPEE AERWIVNLIR NARLDAKIDS KLGHVVMGNN AVSP YQQVI EKTKSLSFRS QMLAMNIEKK LNQNSRSEAP NWATQDSGFY

UniProtKB: Eukaryotic translation initiation factor 3 subunit E

分子 #2: Eukaryotic translation initiation factor 3 subunit F

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit F; タイプ: protein_or_peptide / ID: 2 ; 詳細: Eukaryotic translation initiation factor 3 subunit F; コピー数: 1 / 光学異性体: LEVO / EC番号: ubiquitinyl hydrolase 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 37.593645 KDa

配列

文字列:

MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG QTPASAQAPA QTPAPALPGP ALPGPFPGG RVVRLHPVIL ASIVDSYERR NEGAARVIGT LLGTVDKHSV EVTNCFSVPH NESEDEVAVD MEFAKNMYEL H KKVSPNEL ILGWYATGHD ITEHSVLIHE YYSREAPNPI HLTVDTSLQN GRMSIKAYVS TLMGVPGRTM GVMFTPLTVK YA YYDTERI GVDLIMKTCF SPNRVIGLSS DLQQVGGASA RIQDALSTVL QYAEDVLSGK VSADNTVGRF LMSLVNQVPK IVP DDFETM LNSNINDLLM VTYLANLTQS QIALNEKLVN L

UniProtKB: Eukaryotic translation initiation factor 3 subunit F

分子 #3: Eukaryotic translation initiation factor 3 subunit G

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit G; タイプ: protein_or_peptide / ID: 3 ; 詳細: Eukaryotic translation initiation factor 3 subunit G; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 35.662016 KDa

配列

文字列:

MPTGDFDSKP SWADQVEEEG EDDKCVTSEL LKGIPLATGD TSPEPELLPG APLPPPKEVI NGNIKTVTEY KIDEDGKKFK IVRTFRIET RKASKAVARR KNWKKFGNSE FDPPGPNVAT TTVSDDVSMT FITSKEDLNC QEEEDPMNKL KGQKIVSCRI C KGDHWTTR CPYKDTLGPM QKELAEQLGL STGEKEKLPG ELEPVQATQN KTGKYVPPSL RDGASRRGES MQPNRRADDN AT IRVTNLS EDTRETDLQE LFRPFGSISR IYLAKDKTTG QSKGFAFISF HRREDAARAI AGVSGFGYDH LILNVEWAKP STN

UniProtKB: Eukaryotic translation initiation factor 3 subunit G

分子 #4: Eukaryotic translation initiation factor 3 subunit H

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit H; タイプ: protein_or_peptide / ID: 4 ; 詳細: Eukaryotic translation initiation factor 3 subunit H; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 39.979277 KDa

配列

文字列:

MASRKEGTGS TATSSSSTAG AAGKGKGKGG SGDSAVKQVQ IDGLVVLKII KHYQEEGQGT EVVQGVLLGL VVEDRLEITN CFPFPQHTE DDADFDEVQY QMEMMRSLRH VNIDHLHVGW YQSTYYGSFV TRALLDSQFS YQHAIEESVV LIYDPIKTAQ G SLSLKAYR LTPKLMEVCK EKDFSPEALK KANITFEYMF EEVPIVIKNS HLINVLMWEL EKKSAVADKH ELLSLASSNH LG KNLQLLM DRVDEMSQDI VKYNTYMRNT SKQQQQKHQY QQRRQQENMQ RQSRGEPPLP EEDLSKLFKP PQPPARMDSL LIA GQINTY CQNIKEFTAQ NLGKLFMAQA LQEYNN

UniProtKB: Eukaryotic translation initiation factor 3 subunit H

分子 #5: 60S ribosomal protein L41

• 分子: 名称: 60S ribosomal protein L41 / タイプ: protein_or_peptide / ID: 5 / 詳細: 60S ribosomal protein L41 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 3.473451 KDa

配列

文字列:

MRAKWRKKRM RRLKRKRRKM RQRSK

UniProtKB: Small ribosomal subunit protein eS32

分子 #6: Eukaryotic translation initiation factor 3 subunit A

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit A; タイプ: protein_or_peptide / ID: 6 ; 詳細: Eukaryotic translation initiation factor 3 subunit A; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 166.903781 KDa

配列

文字列:

MPAYFQRPEN ALKRANEFLE VGKKQPALDV LYDVMKSKKH RTWQKIHEPI MLKYLELCVD LRKSHLAKEG LYQYKNICQQ VNIKSLEDV VRAYLKMAEE KTEAAKEESQ QMVLDIEDLD NIQTPESVLL SAVSGEDTQD RTDRLLLTPW VKFLWESYRQ C LDLLRNNS RVERLYHDIA QQAFKFCLQY TRKAEFRKLC DNLRMHLSQI QRHHNQSTAI NLNNPESQSM HLETRLVQLD SA ISMELWQ EAFKAVEDIH GLFSLSKKPP KPQLMANYYN KVSTVFWKSG NALFHASTLH RLYHLSREMR KNLTQDEMQR MST RVLLAT LSIPITPERT DIARLLDMDG IIVEKQRRLA TLLGLQAPPT RIGLINDMVR FNVLQYVVPE VKDLYNWLEV EFNP LKLCE RVTKVLNWVR EQPEKEPELQ QYVPQLQNNT ILRLLQQVSQ IYQSIEFSRL TSLVPFVDAF QLERAIVDAA RHCDL QVRI DHTSRTLSFG SDLNYATRED APIGPHLQSM PSEQIRNQLT AMSSVLAKAL EVIKPAHILQ EKEEQHQLAV TAYLKN SRK EHQRILARRQ TIEERKERLE SLNIQREKEE LEQREAELQK VRKAEEERLR QEAKEREKER ILQEHEQIKK KTVRERL EQ IKKTELGAKA FKDIDIEDLE ELDPDFIMAK QVEQLEKEKK ELQERLKNQE KKIDYFERAK RLEEIPLIKS AYEEQRIK D MDLWEQQEEE RITTMQLERE KALEHKNRMS RMLEDRDLFV MRLKAARQSV YEEKLKQFEE RLAEERHNRL EERKRQRKE ERRITYYREK EEEEQRRAEE QMLKEREERE RAERAKREEE LREYQERVKK LEEVERKKRQ RELEIEERER RREEERRLGD SSLSRKDSR WGDRDSEGTW RKGPEADSEW RRGPPEKEWR RGEGRDEDRS HRRDEERPRR LGDDEDREPS LRPDDDRVPR R GMDDDRGP RRGPEEDRFS RRGADDDRPS WRNTDDDRPP RRIADEDRGN WRHADDDRPP RRGLDEDRGS WRTADEDRGP RR GMDDDRG PRRGGADDER SSWRNADDDR GPRRGLDDDR GPRRGMDDDR GPRRGMDDDR GPRRGMDDDR GPRRGLDDDR GPW RNADDD RIPRRGAEDD RGPWRNMDDD RLSRRADDDR FPRRGDDSRP GPWRPLVKPG GWREKEKARE ESWGPPRESR PSEE REWDR EKERDRDNQD REENDKDPER ERDRERDVDR EDRFRRPRDE GGWRRGPAEE SSSWRDSSRR DDRDRDDRRR ERDDR RDLR ERRDLRDDRD RRGPPLRSER EEVSSWRRAD DRKDDRVEER DPPRRVPPPA LSRDRERDRD REREGEKEKA SWRAEK DRE SLRRTKNETD EDGWTTVRR

UniProtKB: Eukaryotic translation initiation factor 3 subunit A

分子 #7: Eukaryotic translation initiation factor 3 subunit K

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit K; タイプ: protein_or_peptide / ID: 7 ; 詳細: Eukaryotic translation initiation factor 3 subunit K; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 25.083619 KDa

配列

文字列:

MAMFEQMRAN VGKLLKGIDR YNPENLATLE RYVETQAKEN AYDLEANLAV LKLYQFNPAF FQTTVTAQIL LKALTNLPHT DFTLCKCMI DQAHQEERPI RQILYLGDLL ETCHFQAFWQ ALDENMDLLE GITGFEDSVR KFICHVVGIT YQHIDRWLLA E MLGDLSDS QLKVWMSKYG WSADESGQIF ICSQEESIKP KNIVEKIDFD SVSSIMASSQ

UniProtKB: Eukaryotic translation initiation factor 3 subunit K

分子 #8: Eukaryotic translation initiation factor 3 subunit M

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit M; タイプ: protein_or_peptide / ID: 8 ; 詳細: Eukaryotic translation initiation factor 3 subunit M; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 42.555832 KDa

配列

文字列:

MSVPAFIDIS EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV ESVMNSVVSL LLILEPDKQE ALIESLCEK LVKFREGERP SLRLQLLSNL FHGMDKNTPV RYTVYCSLIK VAASCGAIQY IPTELDQVRK WISDWNLTTE K KHTLLRLL YEALVDCKKS DAASKVMVEL LGSYTEDNAS QARVDAHRCI VRALKDPNAF LFDHLLTLKP VKFLEGELIH DL LTIFVSA KLASYVKFYQ NNKDFIDSLG LLHEQNMAKM RLLTFMGMAV ENKEISFDTM QQELQIGADD VEAFVIDAVR TKM VYCKID QTQRKVVVSH STHRTFGKQQ WQQLYDTLNA WKQNLNKVKN SLLSLSDT

UniProtKB: Eukaryotic translation initiation factor 3 subunit M

分子 #9: Eukaryotic translation initiation factor 2 subunit 1

• 分子: 名称: Eukaryotic translation initiation factor 2 subunit 1; タイプ: protein_or_peptide / ID: 9 ; 詳細: Eukaryotic translation initiation factor 2 subunit 1; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 36.16118 KDa

配列

文字列:

MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRR VSPEEAIKCE DKFTKSKTVY SILRHVAEVL EYTKDEQLES LFQRTAWVFD DKYKRPGYGA YDAFKHAVSD P SILDSLDL NEDEREVLIN NINRRLTPQA VKIRADIEVA CYGYEGIDAV KEALRAGLNC STENMPIKIN LIAPPRYVMT TT TLERTEG LSVLSQAMAV IKEKIEEKRG VFNVQMEPKV VTDTDETELA RQMERLEREN AEVDGDDDAE EMEAKAED

UniProtKB: Eukaryotic translation initiation factor 2 subunit 1

分子 #10: Eukaryotic translation initiation factor 2 subunit 3

• 分子: 名称: Eukaryotic translation initiation factor 2 subunit 3; タイプ: protein_or_peptide / ID: 10 ; 詳細: Eukaryotic translation initiation factor 2 subunit 3; コピー数: 1 / 光学異性体: LEVO / EC番号: protein-synthesizing GTPase
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 51.178406 KDa

配列

文字列:

MAGGEAGVTL GQPHLSRQDL TTLDVTKLTP LSHEVISRQA TINIGTIGHV AHGKSTVVKA ISGVHTVRFK NELERNITIK LGYANAKIY KLDDPSCPRP ECYRSCGSST PDEFPTDIPG TKGNFKLVRH VSFVDCPGHD ILMATMLNGA AVMDAALLLI A GNESCPQP QTSEHLAAIE IMKLKHILIL QNKIDLVKES QAKEQYEQIL AFVQGTVAEG APIIPISAQL KYNIEVVCEY IV KKIPVPP RDFTSEPRLI VIRSFDVNKP GCEVDDLKGG VAGGSILKGV LKVGQEIEVR PGIVSKDSEG KLMCKPIFSK IVS LFAEHN DLQYAAPGGL IGVGTKIDPT LCRADRMVGQ VLGAVGALPE IFTELEISYF LLRRLLGVRT EGDKKAAKVQ KLSK NEVLM VNIGSLSTGG RVSAVKADLG KIVLTNPVCT EVGEKIALSR RVEKHWRLIG WGQIRRGVTI KPTVDDD

UniProtKB: Eukaryotic translation initiation factor 2 subunit 3

分子 #11: Eukaryotic translation initiation factor 3 subunit I

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit I; タイプ: protein_or_peptide / ID: 11 ; 詳細: Eukaryotic translation initiation factor 3 subunit I; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 36.543773 KDa

配列

文字列:

MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA DWDTKHVLTG SADNSCRLWD CETGKQLAL LKTNSAVRTC GFDFGGNIIM FSTDKQMGYQ CFVSFFDLRD PSQIDNNEPY MKIPCNDSKI TSAVWGPLGE C IIAGHESG ELNQYSAKSG EVLVNVKEHS RQINDIQLSR DMTMFVTASK DNTAKLFDST TLEHQKTFRT ERPVNSAALS PN YDHVVLG GGQEAMDVTT TSTRIGKFEA RFFHLAFEEE FGRVKGHFGP INSVAFHPDG KSYSSGGEDG YVRIHYFDPQ YFE FEFEA

UniProtKB: Eukaryotic translation initiation factor 3 subunit I

分子 #12: Eukaryotic translation initiation factor 1A, X-chromosomal

• 分子: 名称: Eukaryotic translation initiation factor 1A, X-chromosomal; タイプ: protein_or_peptide / ID: 12 / 詳細: Eukaryotic translation initiation factor 1A / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 16.488449 KDa
• 組換発現: 生物種: Escherichia coli BL21(DE3) (大腸菌)

配列

文字列:

MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKA DVILKYNADE ARSLKAYGEL PEHAKINETD TFGPGDDDEI QFDDIGDDDE DIDDI

UniProtKB: Eukaryotic translation initiation factor 1A, X-chromosomal

分子 #13: Eukaryotic translation initiation factor 5

• 分子: 名称: Eukaryotic translation initiation factor 5 / タイプ: protein_or_peptide / ID: 13 / 詳細: Eukaryotic translation initiation factor 5 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 49.30175 KDa
• 組換発現: 生物種: Escherichia coli BL21(DE3) (大腸菌)

配列

文字列:

MSVNVNRSVS DQFYRYKMPR LIAKVEGKGN GIKTVIVNMV DVAKALNRPP TYPTKYFGCE LGAQTQFDVK NDRYIVNGSH EANKLQDML DGFIKKFVLC PECENPETDL HVNPKKQTIG NSCKACGYRG MLDTHHKLCT FILKNPPENS DSGTGKKEKE K KNRKGKDK ENGSVSSSET PPPPPPPNEI NPPPHTMEEE EDDDWGEDTT EEAQRRRMDE ISDHAKVLTL SDDLERTIEE RV NILFDFV KKKKEEGVID SSDKEIVAEA ERLDVKAMGP LVLTEVLFNE KIREQIKKYR RHFLRFCHNN KKAQRYLLHG LEC VVAMHQ AQLISKIPHI LKEMYDADLL EEEVIISWSE KASKKYVSKE LAKEIRVKAE PFIKWLKEAE EESSGGEEED EDEN IEVVY SKAASVPKVE TVKSDNKDDD IDIDAI

UniProtKB: Eukaryotic translation initiation factor 5

分子 #14: Eukaryotic translation initiation factor 3 subunit B

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit B; タイプ: protein_or_peptide / ID: 14 ; 詳細: Eukaryotic translation initiation factor 3 subunit B; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 92.593414 KDa

配列

文字列:

MQDAENVAVP EAAEERAEPG QQQPAAEPPP AEGLLRPAGP GAPEAAGTEA SSEEVGIAEA GPESEVRTEP AAEAEAASGP SESPSPPAA EELPGSHAEP PVPAQGEAPG EQARDERSDS RAQAVSEDAG GNEGRAAEAE PRALENGDAD EPSFSDPEDF V DDVSEEEL LGDVLKDRPQ EADGIDSVIV VDNVPQVGPD RLEKLKNVIH KIFSKFGKIT NDFYPEEDGK TKGYIFLEYA SP AHAVDAV KNADGYKLDK QHTFRVNLFT DFDKYMTISD EWDIPEKQPF KDLGNLRYWL EEAECRDQYS VIFESGDRTS IFW NDVKDP VSIEERARWT ETYVRWSPKG TYLATFHQRG IALWGGEKFK QIQRFSHQGV QLIDFSPCER YLVTFSPLMD TQDD PQAII IWDILTGHKK RGFHCESSAH WPIFKWSHDG KFFARMTLDT LSIYETPSMG LLDKKSLKIS GIKDFSWSPG GNIIA FWVP EDKDIPARVT LMQLPTRQEI RVRNLFNVVD CKLHWQKNGD YLCVKVDRTP KGTQGVVTNF EIFRMREKQV PVDVVE MKE TIIAFAWEPN GSKFAVLHGE APRISVSFYH VKNNGKIELI KMFDKQQANT IFWSPQGQFV VLAGLRSMNG ALAFVDT SD CTVMNIAEHY MASDVEWDPT GRYVVTSVSW WSHKVDNAYW LWTFQGRLLQ KNNKDRFCQL LWRPRPPTLL SQEQIKQI K KDLKKYSKIF EQKDRLSQSK ASKELVERRR TMMEDFRKYR KMAQELYMEQ KNERLELRGG VDTDELDSNV DDWEEETIE FFVTEEIIPL GNQE

UniProtKB: Eukaryotic translation initiation factor 3 subunit B

分子 #15: Eukaryotic translation initiation factor 3 subunit C

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit C; タイプ: protein_or_peptide / ID: 15 ; 詳細: Eukaryotic translation initiation factor 3 subunit C; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 105.503945 KDa

配列

文字列:

MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL TNLIRTIRNA MKIRDVTKCL EEFELLGKA YGKAKSIVDK EGVPRFYIRI LADLEDYLNE LWEDKEGKKK MNKNNAKALS TLRQKIRKYN RDFESHITSY K QNPEQSAD EDAEKNEEDS EGSSDEDEDE DGVSAATFLK KKSEAPSGES RKFLKKMDDE DEDSEDSEDD EDWDTGSTSS DS DSEEEEG KQTALASRFL KKAPTTDEDK KAAEKKREDK AKKKHDRKSK RLDEEEEDNE GGEWERVRGG VPLVKEKPKM FAK GTEITH AVVIKKLNEI LQARGKKGTD RAAQIELLQL LVQIAAENNL GEGVIVKIKF NIIASLYDYN PNLATYMKPE MWGK CLDCI NELMDILFAN PNIFVGENIL EESENLHNAD QPLRVRGCIL TLVERMDEEF TKIMQNTDPH SQEYVEHLKD EAQVC AIIE RVQRYLEEKG TTEEVCRIYL LRILHTYYKF DYKAHQRQLT PPEGSSKSEQ DQAENEGEDS AVLMERLCKY IYAKDR TDR IRTCAILCHI YHHALHSRWY QARDLMLMSH LQDNIQHADP PVQILYNRTM VQLGICAFRQ GLTKDAHNAL LDIQSSG RA KELLGQGLLL RSLQERNQEQ EKVERRRQVP FHLHINLELL ECVYLVSAML LEIPYMAAHE SDARRRMISK QFHHQLRV G ERQPLLGPPE SMREHVVAAS KAMKMGDWKT CHSFIINEKM NGKVWDLFPE ADKVRTMLVR KIQEESLRTY LFTYSSVYD SISMETLSDM FELDLPTVHS IISKMIINEE LMASLDQPTQ TVVMHRTEPT AQQNLALQLA EKLGSLVENN ERVFDHKQGT YGGYFRDQK DGYRKNEGYM RRGGYRQQQS QTAY

UniProtKB: Eukaryotic translation initiation factor 3 subunit C

分子 #16: Eukaryotic translation initiation factor 3 subunit L

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit L; タイプ: protein_or_peptide / ID: 16 ; 詳細: Eukaryotic translation initiation factor 3 subunit L; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 66.803734 KDa

配列

文字列:

MSYPADDYES EAAYDPYAYP SDYDMHTGDP KQDLAYERQY EQQTYQVIPE VIKNFIQYFH KTVSDLIDQK VYELQASRVS SDVIDQKVY EIQDIYENSW TKLTERFFKN TPWPEAEAIA PQVGNDAVFL ILYKELYYRH IYAKVSGGPS LEQRFESYYN Y CNLFNYIL NADGPAPLEL PNQWLWDIID EFIYQFQSFS QYRCKTAKKS EEEIDFLRSN PKIWNVHSVL NVLHSLVDKS NI NRQLEVY TSGGDPESVA GEYGRHSLYK MLGYFSLVGL LRLHSLLGDY YQAIKVLENI ELNKKSMYSR VPECQVTTYY YVG FAYLMM RRYQDAIRVF ANILLYIQRT KSMFQRTTYK YEMINKQNEQ MHALLAIALT MYPMRIDESI HLQLREKYGD KMLR MQKGD PQVYEELFSY SCPKFLSPVV PNYDNVHPNY HKEPFLQQLK VFSDEVQQQA QLSTIRSFLK LYTTMPVAKL AGFLD LTEQ EFRIQLLVFK HKMKNLVWTS GISALDGEFQ SASEVDFYID KDMIHIADTK VARRYGDFFI RQIHKFEELN RTLKKM GQR P

UniProtKB: Eukaryotic translation initiation factor 3 subunit L

分子 #17: 40S ribosomal protein S7

• 分子: 名称: 40S ribosomal protein S7 / タイプ: protein_or_peptide / ID: 17 / 詳細: Small ribosomal subunit protein eS7 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 22.168914 KDa

配列

文字列:

MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI IIFVPVPQLK SFQKIQVRLV RELEKKFSG KHVVFIAQRR ILPKPTRKSR TKNKQKRPRS RTLTAVHDAI LEDLVFPSEI VGKRIRVKLD GSRLIKVHLD K AQQNNVEH KVETFSGVYK KLTGKDVNFE FPEFQL

UniProtKB: Small ribosomal subunit protein eS7

分子 #18: 40S ribosomal protein S27

• 分子: 名称: 40S ribosomal protein S27 / タイプ: protein_or_peptide / ID: 18 / 詳細: Small ribosomal subunit protein eS27 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 9.480186 KDa

配列

文字列:

MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH

UniProtKB: Small ribosomal subunit protein eS27

分子 #19: 40S ribosomal protein S21

• 分子: 名称: 40S ribosomal protein S21 / タイプ: protein_or_peptide / ID: 19 / 詳細: Small ribosomal subunit protein eS21 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 9.124389 KDa

配列

文字列:

MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR RMGESDDSIL RLAKADGIVS KNF

UniProtKB: Small ribosomal subunit protein eS21

分子 #20: 40S ribosomal protein S2

• 分子: 名称: 40S ribosomal protein S2 / タイプ: protein_or_peptide / ID: 20 / 詳細: Small ribosomal subunit protein uS5 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 31.376516 KDa

配列

文字列:

MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA RGGKAEDKEW MPVTKLGRLV KDMKIKSLEE IYLFSLPIK ESEIIDFFLG ASLKDEVLKI MPVQKQTRAG QRTRFKAFVA IGDYNGHVGL GVKCSKEVAT AIRGAIILAK L SIVPVRRG YWGNKIGKPH TVPCKVTGRC GSVLVRLIPA PRGTGIVSAP VPKKLLMMAG IDDCYTSARG CTATLGNFAK AT FDAISKT YSYLTPDLWK ETVFTKSPYQ EFTDHLVKTH TRVSVQRTQA PAVATT

UniProtKB: Small ribosomal subunit protein uS5

分子 #21: 40S ribosomal protein S3a

• 分子: 名称: 40S ribosomal protein S3a / タイプ: protein_or_peptide / ID: 21 / 詳細: Small ribosomal subunit protein eS1 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 30.002061 KDa

配列

文字列:

MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITE DVQGKNCLTN FHGMDLTRDK MCSMVKKWQT MIEAHVDVKT TDGYLLRLFC VGFTKKRNNQ IRKTSYAQHQ Q VRQIRKKM MEIMTREVQT NDLKEVVNKL IPDSIGKDIE KACQSIYPLH DVFVRKVKML KKPKFELGKL MELHGEGSSS GK ATGDETG AKVERADGYE PPVQESV

UniProtKB: Small ribosomal subunit protein eS1

分子 #22: 40S ribosomal protein SA

• 分子: 名称: 40S ribosomal protein SA / タイプ: protein_or_peptide / ID: 22 / 詳細: Small ribosomal subunit protein uS2 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 32.883938 KDa

配列

文字列:

MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLK FAAATGATPI AGRFTPGTFT NQIQAAFREP RLLVVTDPRA DHQPLTEASY VNLPTIALCN TDSPLRYVDI A IPCNNKGA HSVGLMWWML AREVLRMRGT ISREHPWEVM PDLYFYRDPE EIEKEEQAAA EKAVTKEEFQ GEWTAPAPEF TA TQPEVAD WSEGVQVPSV PIQQFPTEDW SAQPATEDWS AAPTAQATEW VGATTDWS

UniProtKB: Small ribosomal subunit protein uS2

分子 #23: 40S ribosomal protein S26

• 分子: 名称: 40S ribosomal protein S26 / タイプ: protein_or_peptide / ID: 23 / 詳細: Small ribosomal subunit protein eS26 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 13.047532 KDa

配列

文字列:

MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDISEASVFD AYVLPKLYVK LHYCVSCAIH SKVVRNRSR EARKDRTPPP RFRPAGAAPR PPPKPM

UniProtKB: Small ribosomal subunit protein eS26

分子 #24: 40S ribosomal protein S6

• 分子: 名称: 40S ribosomal protein S6 / タイプ: protein_or_peptide / ID: 24 / 詳細: Small ribosomal subunit protein eS6 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 28.751906 KDa

配列

文字列:

MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRT GERKRKSVRG CIVDANLSVL NLVIVKKGEK DIPGLTDTTV PRRLGPKRAS RIRKLFNLSK EDDVRQYVVR K PLNKEGKK PRTKAPKIQR LVTPRVLQHK RRRIALKKQR TKKNKEEAAE YAKLLAKRMK EAKEKRQEQI AKRRRLSSLR AS TSKSESS QK

UniProtKB: Small ribosomal subunit protein eS6

分子 #25: 40S ribosomal protein S14

• 分子: 名称: 40S ribosomal protein S14 / タイプ: protein_or_peptide / ID: 25 / 詳細: Small ribosomal subunit protein uS11 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 16.302772 KDa

配列

文字列:

MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK ETICRVTGGM KVKADRDESS PYAAMLAAQD VAQRCKELG ITALHIKLRA TGGNRTKTPG PGAQSALRAL ARSGMKIGRI EDVTPIPSDS TRRKGGRRGR RL

UniProtKB: Small ribosomal subunit protein uS11

分子 #26: Eukaryotic translation initiation factor 2 subunit 2

• 分子: 名称: Eukaryotic translation initiation factor 2 subunit 2; タイプ: protein_or_peptide / ID: 26 ; 詳細: Eukaryotic translation initiation factor 2 subunit 2; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 38.454484 KDa

配列

文字列:

MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD TQTEETQPSE TKEVEPEPTE DKDLEADEED TRKKDASDDL DDLNFFNQKK KKKKTKKIF DIDEAEEGVK DLKIESDVQE PTEPEDDLDI MLGNKKKKKK NVKFPDEDEI LEKDEALEDE DNKKDDGISF S NQTGPAWA GSERDYTYEE LLNRVFNIMR EKNPDMVAGE KRKFVMKPPQ VVRVGTKKTS FVNFTDICKL LHRQPKHLLA FL LAELGTS GSIDGNNQLV IKGRFQQKQI ENVLRRYIKE YVTCHTCRSP DTILQKDTRL YFLQCETCHS RCSVASIKTG FQA VTGKRA QLRAKAN

UniProtKB: Eukaryotic translation initiation factor 2 subunit 2

分子 #27: 40S ribosomal protein S13

• 分子: 名称: 40S ribosomal protein S13 / タイプ: protein_or_peptide / ID: 27 / 詳細: Small ribosomal subunit protein uS15 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 17.259389 KDa

配列

文字列:

MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI GVILRDSHGV AQVRFVTGNK ILRILKSKGL APDLPEDLY HLIKKAVAVR KHLERNRKDK DAKFRLILIE SRIHRLARYY KTKRVLPPNW KYESSTASAL VA

UniProtKB: Small ribosomal subunit protein uS15

分子 #29: 40S ribosomal protein S11

• 分子: 名称: 40S ribosomal protein S11 / タイプ: protein_or_peptide / ID: 29 / 詳細: Small ribosomal subunit protein uS17 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 18.468826 KDa

配列

文字列:

MADIQTERAY QKQPTIFQNK KRVLLGETGK EKLPRYYKNI GLGFKTPKEA IEGTYIDKKC PFTGNVSIRG RILSGVVTKM KMQRTIVIR RDYLHYIRKY NRFEKRHKNM SVHLSPCFRD VQIGDIVTVG ECRPLSKTVR FNVLKVTKAA GTKKQFQKF

UniProtKB: Small ribosomal subunit protein uS17

分子 #30: 40S ribosomal protein S4, X isoform

• 分子: 名称: 40S ribosomal protein S4, X isoform / タイプ: protein_or_peptide / ID: 30 / 詳細: Small ribosomal subunit protein eS4 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 29.654869 KDa

配列

文字列:

MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDV ISIDKTGENF RLIYDTKGRF AVHRITPEEA KYKLCKVRKI FVGTKGIPHL VTHDARTIRY PDPLIKVNDT I QIDLETGK ITDFIKFDTG NLCMVTGGAN LGRIGVITNR ERHPGSFDVV HVKDANGNSF ATRLSNIFVI GKGNKPWISL PR GKGIRLT IAEERDKRLA AKQSSG

UniProtKB: Small ribosomal subunit protein eS4, X isoform

分子 #31: 40S ribosomal protein S9

• 分子: 名称: 40S ribosomal protein S9 / タイプ: protein_or_peptide / ID: 31 / 詳細: Small ribosomal subunit protein uS4 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 22.641564 KDa

配列

文字列:

MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL LTLDEKDPRR LFEGNALLRR LVRIGVLDE GKMKLDYILG LKIEDFLERR LQTQVFKLGL AKSIHHARVL IRQRHIRVRK QVVNIPSFIV RLDSQKHIDF S LRSPYGGG RPGRVKRKNA KKGQGGAGAG DDEEED

UniProtKB: Small ribosomal subunit protein uS4

分子 #32: 40S ribosomal protein S23

• 分子: 名称: 40S ribosomal protein S23 / タイプ: protein_or_peptide / ID: 32 / 詳細: Small ribosomal subunit protein uS12 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.844666 KDa

配列

文字列:

MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDG CLNFIEENDE VLVAGFGRKG HAVGDIPGVR FKVVKVANVS LLALYKGKKE RPRS

UniProtKB: Small ribosomal subunit protein uS12

分子 #33: 40S ribosomal protein S30

• 分子: 名称: 40S ribosomal protein S30 / タイプ: protein_or_peptide / ID: 33 / 詳細: Small ribosomal subunit protein eS30 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 6.668938 KDa

配列

文字列:

KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG KKKGPNANS

UniProtKB: Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

分子 #34: 40S ribosomal protein S15a

• 分子: 名称: 40S ribosomal protein S15a / タイプ: protein_or_peptide / ID: 34 / 詳細: Small ribosomal subunit protein uS8 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 14.865555 KDa

配列

文字列:

MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKW QNNLLPSRQF GFIVLTTSAG IMDHEEARRK HTGGKILGFF F

UniProtKB: Small ribosomal subunit protein uS8

分子 #35: 40S ribosomal protein S8

• 分子: 名称: 40S ribosomal protein S8 / タイプ: protein_or_peptide / ID: 35 / 詳細: Small ribosomal subunit protein eS8 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 24.263387 KDa

配列

文字列:

MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNE LVRTKTLVKN CIVLIDSTPY RQWYESHYAL PLGRKKGAKL TPEEEEILNK KRSKKIQKKY DERKKNAKIS S LLEEQFQQ GKLLACIASR PGQCGRADGY VLEGKELEFY LRKIKARKGK

UniProtKB: Small ribosomal subunit protein eS8

分子 #36: 40S ribosomal protein S24

• 分子: 名称: 40S ribosomal protein S24 / タイプ: protein_or_peptide / ID: 36 / 詳細: Small ribosomal subunit protein eS24 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.463333 KDa

配列

文字列:

MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKH RLARHGLYEK KKTSRKQRKE RKNRMKKVRG TAKANVGAGK KPKE

UniProtKB: Small ribosomal subunit protein eS24

分子 #37: 40S ribosomal protein S5

• 分子: 名称: 40S ribosomal protein S5 / タイプ: protein_or_peptide / ID: 37 / 詳細: Small ribosomal subunit protein uS7 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 22.913453 KDa

配列

文字列:

MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR FRKAQCPIVE RLTNSMMMHG RNNGKKLMT VRIVKHAFEI IHLLTGENPL QVLVNAIINS GPREDSTRIG RAGTVRRQAV DVSPLRRVNQ AIWLLCTGAR E AAFRNIKT IAECLADELI NAAKGSSNSY AIKKKDELER VAKSNR

UniProtKB: Small ribosomal subunit protein uS7

分子 #38: 40S ribosomal protein S16

• 分子: 名称: 40S ribosomal protein S16 / タイプ: protein_or_peptide / ID: 38 / 詳細: Small ribosomal subunit protein uS9 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 16.477377 KDa

配列

文字列:

MPSKGPLQSV QVFGRKKTAT AVAHCKRGNG LIKVNGRPLE MIEPRTLQYK LLEPVLLLGK ERFAGVDIRV RVKGGGHVAQ IYAIRQSIS KALVAYYQKY VDEASKKEIK DILIQYDRTL LVADPRRCES KKFGGPGARA RYQKSYR

UniProtKB: Small ribosomal subunit protein uS9

分子 #39: 40S ribosomal protein S3

• 分子: 名称: 40S ribosomal protein S3 / タイプ: protein_or_peptide / ID: 39 / 詳細: Small ribosomal subunit protein uS3 / コピー数: 1 / 光学異性体: LEVO / EC番号: DNA-(apurinic or apyrimidinic site) lyase
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 26.729369 KDa

配列

文字列:

MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAE KVATRGLCAI AQAESLRYKL LGGLAVRRAC YGVLRFIMES GAKGCEVVVS GKLRGQRAKS MKFVDGLMIH S GDPVNYYV DTAVRHVLLR QGVLGIKVKI MLPWDPTGKI GPKKPLPDHV SIVEPKDEIL PTTPISEQKG GKPEPPAMPQ PV PTA

UniProtKB: Small ribosomal subunit protein uS3

分子 #40: 40S ribosomal protein S10

• 分子: 名称: 40S ribosomal protein S10 / タイプ: protein_or_peptide / ID: 40 / 詳細: Small ribosomal subunit protein eS10 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 18.933846 KDa

配列

文字列:

MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEI VPATLRRSRP ETGRPRPKGL EGERPARLTR GEADRDTYRR SAVPPGADKK AEAGAGSATE FQFRGGFGRG R GQPPQ

UniProtKB: Small ribosomal subunit protein eS10

分子 #41: 40S ribosomal protein S15

• 分子: 名称: 40S ribosomal protein S15 / タイプ: protein_or_peptide / ID: 41 / 詳細: Small ribosomal subunit protein uS19 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 17.076207 KDa

配列

文字列:

MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEM VGSMVGVYNG KTFNQVEIKP EMIGHYLGEF SITYKPVKHG RPGIGATHSS RFIPLK

UniProtKB: Small ribosomal subunit protein uS19

分子 #42: Receptor of activated protein C kinase 1

• 分子: 名称: Receptor of activated protein C kinase 1 / タイプ: protein_or_peptide / ID: 42 / 詳細: Receptor of activated protein C kinase 1 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 35.115652 KDa

配列

文字列:

MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRL WDLTTGTTTR RFVGHTKDVL SVAFSSDNRQ IVSGSRDKTI KLWNTLGVCK YTVQDESHSE WVSCVRFSPN S SNPIIVSC GWDKLVKVWN LANCKLKTNH IGHTGYLNTV TVSPDGSLCA SGGKDGQAML WDLNEGKHLY TLDGGDIINA LC FSPNRYW LCAATGPSIK IWDLEGKIIV DELKQEVIST SSKAEPPQCT SLAWSADGQT LFAGYTDNLV RVWQVTIGTR

UniProtKB: Small ribosomal subunit protein RACK1

分子 #43: 40S ribosomal protein S19

• 分子: 名称: 40S ribosomal protein S19 / タイプ: protein_or_peptide / ID: 43 / 詳細: Small ribosomal subunit protein eS19 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 16.091562 KDa

配列

文字列:

MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMP SHFSRGSKSV ARRVLQALEG LKMVEKDQDG GRKLTPQGQR DLDRIAGQVA AANKKH

UniProtKB: Small ribosomal subunit protein eS19

分子 #44: 40S ribosomal protein S25

• 分子: 名称: 40S ribosomal protein S25 / タイプ: protein_or_peptide / ID: 44 / 詳細: Small ribosomal subunit protein eS25 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 13.776224 KDa

配列

文字列:

MPPKDDKKKK DAGKSAKKDK DPVNKSGGKA KKKKWSKGKV RDKLNNLVLF DKATYDKLCK EVPNYKLITP AVVSERLKIR GSLARAALQ ELLSKGLIKL VSKHRAQVIY TRNTKGGDAP AAGEDA

UniProtKB: Small ribosomal subunit protein eS25

分子 #45: Small ribosomal subunit protein uS13

• 分子: 名称: Small ribosomal subunit protein uS13 / タイプ: protein_or_peptide / ID: 45 / 詳細: Small ribosomal subunit protein uS13 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 17.630598 KDa

配列

文字列:

MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQKD VKDGKYSQVL ANGLDNKLRE DLERLKKIRA HRGLRHFWGL RVRGQHTKTT GRRGRTVGVS KK

UniProtKB: Small ribosomal subunit protein uS13

分子 #46: 40S ribosomal protein S29

• 分子: 名称: 40S ribosomal protein S29 / タイプ: protein_or_peptide / ID: 46 / 詳細: Small ribosomal subunit protein uS14 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 6.690821 KDa

配列

文字列:

MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKLD

UniProtKB: Small ribosomal subunit protein uS14

分子 #47: Ubiquitin-40S ribosomal protein S27a

• 分子: 名称: Ubiquitin-40S ribosomal protein S27a / タイプ: protein_or_peptide / ID: 47 / 詳細: Small ribosomal subunit protein eS31 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 18.004041 KDa

配列

文字列:

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGAKKR KKKSYTTPK KNKHKRKKVK LAVLKYYKVD ENGKISRLRR ECPSDECGAG VFMASHFDRH YCGKCCLTYC FNKPEDK

UniProtKB: Ubiquitin-ribosomal protein eS31 fusion protein

分子 #48: 40S ribosomal protein S12

• 分子: 名称: 40S ribosomal protein S12 / タイプ: protein_or_peptide / ID: 48 / 詳細: Small ribosomal subunit protein eS12 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 14.538987 KDa

配列

文字列:

MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VLASNCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWV GLCKIDREGK PRKVVGCSCV VVKDYGKESQ AKDVIEEYFK CKK

UniProtKB: Small ribosomal subunit protein eS12

分子 #49: 40S ribosomal protein S28

• 分子: 名称: 40S ribosomal protein S28 / タイプ: protein_or_peptide / ID: 49 / 詳細: Small ribosomal subunit protein eS28 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 7.855052 KDa

配列

文字列:

MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV REGDVLTLLE SEREARRLR

UniProtKB: Small ribosomal subunit protein eS28

分子 #50: 40S ribosomal protein S17

• 分子: 名称: 40S ribosomal protein S17 / タイプ: protein_or_peptide / ID: 50 / 詳細: Small ribosomal subunit protein eS17 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.578156 KDa

配列

文字列:

MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR IQRGPVRGIS IKLQEEERER RDNYVPEVS ALDQEIIEVD PDTKEMLKLL DFGSLSNLQV TQPTVGMNFK TPRGPV

UniProtKB: Small ribosomal subunit protein eS17

分子 #51: 40S ribosomal protein S20

• 分子: 名称: 40S ribosomal protein S20 / タイプ: protein_or_peptide / ID: 51 / 詳細: Small ribosomal subunit protein uS10 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 13.398763 KDa

配列

文字列:

MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV KGPVRMPTKT LRITTRKTPC GEGSKTWDRF QMRIHKRLI DLHSPSEIVK QITSISIEPG VEVEVTIADA

UniProtKB: Small ribosomal subunit protein uS10

分子 #52: Eukaryotic translation initiation factor 3 subunit D

• 分子: 名称: Eukaryotic translation initiation factor 3 subunit D; タイプ: protein_or_peptide / ID: 52 ; 詳細: Eukaryotic translation initiation factor 3 subunit D; コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 64.060758 KDa

配列

文字列:

MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS SQFGGGSQYA YFHEEDESSF QLVDTARTQ KTAYQRNRMR FAQRNLRRDK DRRNMLQFNL QILPKSAKQK ERERIRLQKK FQKQFGVRQK WDQKSQKPRD S SVEVRSDW EVKEEMDFPQ LMKMRYLEVS EPQDIECCGA LEYYDKAFDR ITTRSEKPLR SIKRIFHTVT TTDDPVIRKL AK TQGNVFA TDAILATLMS CTRSVYSWDI VVQRVGSKLF FDKRDNSDFD LLTVSETANE PPQDEGNSFN SPRNLAMEAT YIN HNFSQQ CLRMGKERYN FPNPNPFVED DMDKNEIASV AYRYRRWKLG DDIDLIVRCE HDGVMTGANG EVSFINIKTL NEWD SRHCN GVDWRQKLDS QRGAVIATEL KNNSYKLARW TCCALLAGSE YLKLGYVSRY HVKDSSRHVI LGTQQFKPNE FASQI NLSV ENAWGILRCV IDICMKLEEG KYLILKDPNK QVIRVYSLPD GTFSSDEDEE EEEEEEEEEE EEET

UniProtKB: Eukaryotic translation initiation factor 3 subunit D

分子 #55: Eukaryotic initiation factor 4A-I

• 分子: 名称: Eukaryotic initiation factor 4A-I / タイプ: protein_or_peptide / ID: 55 / 詳細: Eukaryotic initiation factor 4A-I / コピー数: 2 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 46.207824 KDa
• 組換発現: 生物種: Escherichia coli BL21(DE3) (大腸菌)

配列

文字列:

MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY GFEKPSAIQQ RAILPCIKGY DVIAQAQSGT GKTATFAIS ILQQIELDLK ATQALVLAPT RELAQQIQKV VMALGDYMGA SCHACIGGTN VRAEVQKLQM EAPHIIVGTP G RVFDMLNR RYLSPKYIKM FVLDEADEML SRGFKDQIYD IFQKLNSNTQ VVLLSATMPS DVLEVTKKFM RDPIRILVKK EE LTLEGIR QFYINVEREE WKLDTLCDLY ETLTITQAVI FINTRRKVDW LTEKMHARDF TVSAMHGDMD QKERDVIMRE FRS GSSRVL ITTDLLARGI DVQQVSLVIN YDLPTNRENY IHRIGRGGRF GRKGVAINMV TEEDKRTLRD IETFYNTSIE EMPL NVADL I

UniProtKB: Eukaryotic initiation factor 4A-I

分子 #56: Eukaryotic translation initiation factor 4 gamma 1

• 分子: 名称: Eukaryotic translation initiation factor 4 gamma 1 / タイプ: protein_or_peptide / ID: 56 / 詳細: Eukaryotic translation initiation factor 4 gamma / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 155.130141 KDa
• 組換発現: 生物種: Baculovirus expression vector pFastBac1-HM (ウイルス)

配列

文字列:

MSGARTASTP TPPQTGGGLE PQANGETPQV AVIVRPDDRS QGAIIADRPG LPGPEHSPSE SQPSSPSPTP SPSPVLEPGS EPNLAVLSI PGDTMTTIQM SVEESTPISR ETGEPYRLSP EPTPLAEPIL EVEVTLSKPV PESEFSSSPL QAPTPLASHT V EIHEPNGM VPSEDLEPEV ESSPELAPPP ACPSESPVPI APTAQPEELL NGAPSPPAVD LSPVSEPEEQ AKEVTASMAP PT IPSATPA TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE AESEKGGEEL LPPESTPIPA NLSQNLEAAA ATQVAVSVPK RRR KIKELN KKEAVGDLLD AFKEANPAVP EVENQPPAGS NPGPESEGSG VPPRPEEADE TWDSKEDKIH NAENIQPGEQ KYEY KSDQW KPLNLEEKKR YDREFLLGFQ FIFASMQKPE GLPHISDVVL DKANKTPLRP LDPTRLQGIN CGPDFTPSFA NLGRT TLST RGPPRGGPGG ELPRGPQAGL GPRRSQQGPR KEPRKIIATV LMTEDIKLNK AEKAWKPSSK RTAADKDRGE EDADGS KTQ DLFRRVRSIL NKLTPQMFQQ LMKQVTQLAI DTEERLKGVI DLIFEKAISE PNFSVAYANM CRCLMALKVP TTEKPTV TV NFRKLLLNRC QKEFEKDKDD DEVFEKKQKE MDEAATAEER GRLKEELEEA RDIARRRSLG NIKFIGELFK LKMLTEAI M HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKII KEKKTSSRIR FMLQDVLDLR GSNWVPRRG DQGPKTIDQI HKEAEMEEHR EHIKVQQLMA KGSDKRRGGP PGPPISRGLP LVDDGGWNTV PISKGSRPID TSRLTKITKP GSIDSNNQL FAPGGRLSWG KGSSGGSGAK PSDAASEAAR PATSTLNRFS ALQQAVPTES TDNRRVVQRS SLSRERGEKA G DRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KA ALSEEEL EKKSKAIIEE YLHLNDMKEA VQCVQELASP SLLFIFVRHG VESTLERSAI AREHMGQLLH QLLCAGHLST AQY YQGLYE ILELAEDMEI DIPHVWLYLA ELVTPILQEG GVPMGELFRE ITKPLRPLGK AASLLLEILG LLCKSMGPKK VGTL WREAG LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS EELNRQLEKL LKEGSSNQRV FDWIEANLSE QQIVS NTLV RALMTAVCYS AIIFETPLRV DVAVLKARAK LLQKYLCDEQ KELQALYALQ ALVVTLEQPP NLLRMFFDAL YDEDVV KED AFYSWESSKD PAEQQGKGVA LKSVTAFFKW LREAEEESDH N

UniProtKB: Eukaryotic translation initiation factor 4 gamma 1

分子 #28: 18S rRNA

• 分子: 名称: 18S rRNA / タイプ: rna / ID: 28 / 詳細: 18S rRNA / コピー数: 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 555.083875 KDa

配列

文字列:

UACCUGGUUG AUCCUGCCAG UAGCAU(A2M)UGC UUGUCUCAAA GAUUAAGCCA UGCAUGUCUG AGUACGCACG GCCGGU ACA GUGAAACUGC GAAUGGCUCA UUAAAUCAGU UAUGGU(OMU)CC(PSU) U(OMU)GGUCGCUC GCUCCUACUU GGAUA ACUG UGGUA(A2M)UUCU AG(A2M)GCUAAUA (OMC)AUGCCGACG GGCGCUGACC CCCUUCGCGG GGGGGAUGCG UGCA UUUAU CAGUGGUGAC UCUAGAUAAC CUCGGGCCGA UCGCACGCCC CCCGUGGCGG CGACGACCCA UUCGAACGUC UGCCC UAUC AACUUUCGAU GGUAGUCGCC GUGCCUACCA UGGUGACCAC GGGUGACGGG GAAUCAGGGU UCGAUUCCGG AGAGGG AGC CUGAGAAACG GCUACCACAU CCAAGGAAGG CAGCAGGCGC GC(A2M)AAUUACC CACUCCCGAC CCGGGGA(OMG)G UAGUGA(OMC)GAA AAAUAACAAU ACAGGACUCU UUCGAGGCCC UGUAAUUGGA AUGAGUCCAC UUUAAAUCCU UUAACG AGG AUCCAUUGGA GGGCAAGUCU GG(PSU)GCCAGCA GCCGCGGUAA UUCCAGCUCC AAUA(OMG)CGUAU AUUAAAGUU GCUGCAGUU(A2M) AAAAGCUCGU AGUU(OMG)GAUCU UGGGAGCGGC CCCGCCCCUC UCGGCGGCCC GAAGCGUUUA CU UUGAAAA AA(5MU)UAGAGUG (PSU)(PSU)CAAAGCAG GCCCGAGCCG CCUGGAUACC GCAGCUAGGA AUAAUGGAAU A GGACCGCG GUUCUAUUUU GUUGGUUUUC GGAACUGAGG CCAUGAUUAA GAGGGACGGC CGGGGGCAUU CGUAUUGCGC CG CUAGAGG UGAAAUUCUU GGACCGGCGC AAGACGGACC AGAGCGAAAG CAUUUGCCAA GAAUGUUUUC AUUAAUCAAG A (A2M)CGAAAGU CGGAGGUUCG AAGACGAUCA GAUACCGUCG UAGUUCCGAC CA(PSU)AAACGAU GCCGACCGGC GAUG CGGCG GCGUUAUUCC CAUGACCCGC CGGGCAGCUU CCGGGAAACC AAAGUCUUUG GGUUCCGGGG GGAGUAUGGU UGCAA AGCU GAAACUUAAA GGAAUUGACG GAAGGGCACC AC(JMH)AGGAGUG GAGCCUGCGG CUUAAU(PSU)UGA C(C4J)CA ACACG GGAAACCUCA CCCGGCCCGG ACACGGACAG GAUUGACAGA UUGAUAGCUC UUUCUCGAUU CCGUGGGUGG UGGUG CAUG GCCGUUCUUA GUUGGUGGAG CGAUUUGUCU GGUUAAUUC(5MC) GAUAACGAAC GAGACUCUGG CAUGCUAACU AG UUACGCG ACCCCCGAGC GGUCGGCGUC CCCCAACUUC UUAGAGGGAC AAGUGGCGUU CAGCCACCCG AGAUUGAGCA AUA ACAGGU CUGUGAUGCC CUUAGAUGUC CGGGGCUGCA CGCGCGCUAC ACUGACUGGC UCAGCGUGUG CCUACCCUAC GCCG GCAGG CGCGGGUAAC CCGUUGAACC CCAUUCGUGA UGGGGAUCGG GGAUUGCAAU UAUUCCCCAU GAACGAGGAA UUCCC AGUA AGUGCGGGUC AUAAGCUUGC GUUGAUU(A2M)AG UCCCUGCCCU UUGUACACAC CG(OMC)CCGUCGC UACUACCG A UUGGAUGGUU UAGUGAGGCC CUCGGAUCGG CCCCGCCGGG GGCCCUGGCG GAGCGCUGAG AAGACGGUCG AACUUGACU AUCUAGAGGA AGUAAAAGUC G(UR3)A(6MZ)CAAGGU UUCCGUAGGU G(MA6)(MA6)CCUGCGG AAGGAUCAUU A

分子 #53: tRNAiMet

• 分子: 名称: tRNAiMet / タイプ: rna / ID: 53 / 詳細: Human initiator Met-tRNA-i / コピー数: 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 24.23151 KDa

配列

文字列:

AGCAGAGUGG CGCAGCGGAA GCGUGCUGGG CCCAUAACCC AGAGGUCGAU GGAUCGAAAC CAUCCUCUGC UACCA

GENBANK: GENBANK: K00328.1

分子 #54: mRNA

• 分子: 名称: mRNA / タイプ: rna / ID: 54 / 詳細: mRNA / コピー数: 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 67.626453 KDa

配列

文字列:

GGACAAGAGA GAGAGAGACU CCAACUCCAA GAGAGAGAGA GACAACUCCA AGAGAGAGAG AGACAAACCC UCGCUGAGCC GCAGUCAGA UCCUAGCGUC GAGUUGAUGC UGUCCGAUAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A AAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAA

分子 #57: ZINC ION

• 分子: 名称: ZINC ION / タイプ: ligand / ID: 57 / コピー数: 2 / 式: ZN
• 分子量: 理論値: 65.409 Da

分子 #58: MAGNESIUM ION

• 分子: 名称: MAGNESIUM ION / タイプ: ligand / ID: 58 / コピー数: 89 / 式: MG
• 分子量: 理論値: 24.305 Da

実験情報

構造解析

• 手法: クライオ電子顕微鏡法
• 解析: 単粒子再構成法
• 試料の集合状態: particle

試料調製

• 緩衝液: pH: 7.4
• グリッド: モデル: UltrAuFoil R1.2/1.3 / 支持フィルム - 材質: GRAPHENE OXIDE / 前処理 - タイプ: GLOW DISCHARGE
• 凍結: 凍結剤: ETHANE / チャンバー内湿度: 100 % / チャンバー内温度: 277.15 K

電子顕微鏡法

• 顕微鏡: FEI TITAN KRIOS
• ソフトウェア: 名称: EPU
• 撮影: フィルム・検出器のモデル: GATAN K3 (6k x 4k) / 平均電子線量: 47.88 e/Ų
• 電子線: 加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
• 電子光学系: 照射モード: OTHER / 撮影モード: OTHER / 最大 デフォーカス（公称値）: 3.0 µm / 最小 デフォーカス（公称値）: 1.2 µm
• 試料ステージ: 試料ホルダーモデル: FEI TITAN KRIOS AUTOGRID HOLDER; ホルダー冷却材: NITROGEN
• 実験機器: モデル: Titan Krios / 画像提供: FEI Company

画像解析

• 初期モデル: モデルのタイプ: OTHER
• 最終 再構成: 解像度のタイプ: BY AUTHOR / 解像度: 3.5 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 241389
• 初期 角度割当: タイプ: OTHER
• 最終 角度割当: タイプ: OTHER