eF-site ID 6o8b-B PDB Code 6o8b Chain B click to enlarge Title Crystal structure of STING CTD in complex with TBK1 Classification IMMUNE SYSTEM Compound Stimulator of interferon genes protein Source (TBK1_HUMAN) Sequence B:  DGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAI KVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEET TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR DVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTD FGAARELEDDEQFVELYGTEEYLHPDMYERAVLRKDHQKK YGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLL TPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQ QMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGR RLVLEPGRLAQHFPKTTEENPIFVVSREPLDTIGLIYEKI SLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQE LMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEK TVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIET SLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLN CMTEIYYQFKKDQAERRLAYNEEQIHKFDKQKLYYHATKA MTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQC FDIEEEVSKYQEYTNEL Description Functional site 1) chain B residue 15 type sequence L description binding site for residue BX7 B 701 source : AC2 2) chain B residue 16 type sequence G description binding site for residue BX7 B 701 source : AC2 3) chain B residue 17 type sequence Q description binding site for residue BX7 B 701 source : AC2 4) chain B residue 18 type sequence G description binding site for residue BX7 B 701 source : AC2 5) chain B residue 23 type sequence V description binding site for residue BX7 B 701 source : AC2 6) chain B residue 36 type sequence A description binding site for residue BX7 B 701 source : AC2 7) chain B residue 38 type sequence K description binding site for residue BX7 B 701 source : AC2 8) chain B residue 86 type sequence M description binding site for residue BX7 B 701 source : AC2 9) chain B residue 88 type sequence F description binding site for residue BX7 B 701 source : AC2 10) chain B residue 89 type sequence C description binding site for residue BX7 B 701 source : AC2 11) chain B residue 92 type sequence G description binding site for residue BX7 B 701 source : AC2 12) chain B residue 93 type sequence S description binding site for residue BX7 B 701 source : AC2 13) chain B residue 95 type sequence Y description binding site for residue BX7 B 701 source : AC2 14) chain B residue 139 type sequence G description binding site for residue BX7 B 701 source : AC2 15) chain B residue 142 type sequence M description binding site for residue BX7 B 701 source : AC2 16) chain B residue 156 type sequence T description binding site for residue BX7 B 701 source : AC2 17) chain B residue 157 type sequence D description binding site for residue BX7 B 701 source : AC2 18) chain B residue 135 type ACT_SITE sequence N description Proton acceptor => ECO:0000305|PubMed:23453971, ECO:0000305|PubMed:23453972, ECO:0000305|PubMed:30842653 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 15 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 38 type BINDING sequence K description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 172 type MOD_RES sequence E description Phosphoserine; by autocatalysis and IKKB => ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23746807 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 30 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971 source Swiss-Prot : SWS_FT_FI5 23) chain B residue 401 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971 source Swiss-Prot : SWS_FT_FI5

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