eF-site ID 6fuj-A
PDB Code 6fuj
Chain A

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Title Complement factor D in complex with the inhibitor N-(3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)-3-methylbutanamide
Classification HYDROLASE
Compound Complement factor D
Source (CFAD_HUMAN)
Sequence A:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA
HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD
SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG
TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH
DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG
SRVCGNRKKPGIYTRVASYAAWIDSVLA
Description (1)  Complement factor D (E.C.3.4.21.46)


Functional site

1) chain A
residue 96
type
sequence P
description binding site for residue E8B A 301
source : AC1

2) chain A
residue 189
type
sequence D
description binding site for residue E8B A 301
source : AC1

3) chain A
residue 190
type
sequence S
description binding site for residue E8B A 301
source : AC1

4) chain A
residue 191
type
sequence C
description binding site for residue E8B A 301
source : AC1

5) chain A
residue 192
type
sequence K
description binding site for residue E8B A 301
source : AC1

6) chain A
residue 195
type
sequence S
description binding site for residue E8B A 301
source : AC1

7) chain A
residue 215
type
sequence S
description binding site for residue E8B A 301
source : AC1

8) chain A
residue 218
type
sequence R
description binding site for residue E8B A 301
source : AC1

9) chain A
residue 218
type
sequence R
description binding site for residue E8B A 301
source : AC1

10) chain A
residue 219
type
sequence V
description binding site for residue E8B A 301
source : AC1

11) chain A
residue 53-58
type prosite
sequence LSAAHC
description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
source prosite : PS00134

12) chain A
residue 189-200
type prosite
sequence DSCKGDSGGPLV
description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
source prosite : PS00135

13) chain A
residue 57
type ACT_SITE
sequence H
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 102
type ACT_SITE
sequence D
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

15) chain A
residue 195
type ACT_SITE
sequence S
description Charge relay system
source Swiss-Prot : SWS_FT_FI1


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