eF-site ID 5vmp-D PDB Code 5vmp Chain D click to enlarge Title Crystal Structure of Human KDM4 with Small Molecule Inhibitor QC5714 Classification OXIDOREDUCTASE/INHIBITOR Compound Lysine-specific demethylase 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence D:  SETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGL AKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQ YNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKN LTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKES GVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWY SVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLM LKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAEST NFATRRWIEYGKQAVLCSCRVKISMDVFVRKFQPERYKLW KAGKDNTVIDHTLPTPEAAEF Description Functional site 1) chain D residue 188 type sequence H description binding site for residue NI D 501 source : AD1 2) chain D residue 190 type sequence E description binding site for residue NI D 501 source : AD1 3) chain D residue 276 type sequence H description binding site for residue NI D 501 source : AD1 4) chain D residue 234 type sequence C description binding site for residue ZN D 502 source : AD2 5) chain D residue 240 type sequence H description binding site for residue ZN D 502 source : AD2 6) chain D residue 306 type sequence C description binding site for residue ZN D 502 source : AD2 7) chain D residue 308 type sequence C description binding site for residue ZN D 502 source : AD2 8) chain D residue 86 type sequence N description binding site for residue 9FJ D 503 source : AD3 9) chain D residue 132 type sequence Y description binding site for residue 9FJ D 503 source : AD3 10) chain D residue 184 type sequence S description binding site for residue 9FJ D 503 source : AD3 11) chain D residue 185 type sequence F description binding site for residue 9FJ D 503 source : AD3 12) chain D residue 188 type sequence H description binding site for residue 9FJ D 503 source : AD3 13) chain D residue 206 type sequence K description binding site for residue 9FJ D 503 source : AD3 14) chain D residue 240 type sequence H description binding site for residue 9FJ D 503 source : AD3 15) chain D residue 241 type sequence K description binding site for residue 9FJ D 503 source : AD3 16) chain D residue 276 type sequence H description binding site for residue 9FJ D 503 source : AD3 17) chain D residue 177 type catalytic sequence Y description 370 source MCSA : MCSA4 18) chain D residue 188 type catalytic sequence H description 370 source MCSA : MCSA4 19) chain D residue 190 type catalytic sequence E description 370 source MCSA : MCSA4 20) chain D residue 276 type catalytic sequence H description 370 source MCSA : MCSA4 21) chain D residue 288 type catalytic sequence S description 370 source MCSA : MCSA4 22) chain D residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 26) chain D residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 27) chain D residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 28) chain D residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 29) chain D residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 30) chain D residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 31) chain D residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 32) chain D residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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