5VMP

Crystal Structure of Human KDM4 with Small Molecule Inhibitor QC5714

Summary for 5VMP

Entry DOI	10.2210/pdb5vmp/pdb
Descriptor	Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
Functional Keywords	kdm4, inhibitor-complex, demethylase, epigenetics, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : O75164
Total number of polymer chains	4
Total formula weight	173648.94
Authors	Hosfield, D.J. (deposition date: 2017-04-28, release date: 2017-09-27, Last modification date: 2023-10-04)
Primary citation	Chen, Y.K.,Bonaldi, T.,Cuomo, A.,Del Rosario, J.R.,Hosfield, D.J.,Kanouni, T.,Kao, S.C.,Lai, C.,Lobo, N.A.,Matuszkiewicz, J.,McGeehan, A.,O'Connell, S.M.,Shi, L.,Stafford, J.A.,Stansfield, R.K.,Veal, J.M.,Weiss, M.S.,Yuen, N.Y.,Wallace, M.B. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett, 8:869-874, 2017 Cited by PubMed: 28835804 DOI: 10.1021/acsmedchemlett.7b00220 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation