|
eF-site ID
|
5nvn-D |
PDB Code
|
5nvn |
Chain
|
D |
|
click to enlarge
|
|
Title
|
Crystal structure of the human 4EHP-4E-BP1 complex |
Classification
|
TRANSLATION |
Compound
|
Eukaryotic translation initiation factor 4E type 2 |
Source
|
Homo sapiens (Human) (4EBP1_HUMAN) |
|
Sequence
|
D: |
MTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTS
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
D |
residue |
56 |
type |
|
sequence |
R
|
description |
binding site for residue FMT C 305
|
source |
: AC6
|
|
2)
|
chain |
D |
residue |
50 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
D |
residue |
54 |
type |
MOD_RES |
sequence |
Y
|
description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
D |
residue |
65 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
5)
|
chain |
D |
residue |
70 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine; by MTOR => ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
6)
|
chain |
D |
residue |
77 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine => ECO:0007744|PubMed:24275569
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
7)
|
chain |
D |
residue |
83 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0007744|PubMed:18669648
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
8)
|
chain |
D |
residue |
57 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
|
|