5NVN

Crystal structure of the human 4EHP-4E-BP1 complex

Summary for 5NVN

Entry DOI	10.2210/pdb5nvn/pdb
Descriptor	Eukaryotic translation initiation factor 4E type 2, Eukaryotic translation initiation factor 4E-binding protein 1, FORMIC ACID, ... (4 entities in total)
Functional Keywords	translational regulation, translation initiation, cap-binding protein, eif4e-binding protein 1, translation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	52946.55
Authors	Peter, D.,Sandmeir, F.,Valkov, E. (deposition date: 2017-05-04, release date: 2017-07-26, Last modification date: 2024-01-17)
Primary citation	Peter, D.,Weber, R.,Sandmeir, F.,Wohlbold, L.,Helms, S.,Bawankar, P.,Valkov, E.,Igreja, C.,Izaurralde, E. GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31:1147-1161, 2017 Cited by PubMed: 28698298 DOI: 10.1101/gad.299420.117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation