|
|
eF-site ID
|
5nvn-A |
|
PDB Code
|
5nvn |
|
Chain
|
A |
|
click to enlarge
|
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Title
|
Crystal structure of the human 4EHP-4E-BP1 complex |
|
Classification
|
TRANSLATION |
|
Compound
|
Eukaryotic translation initiation factor 4E type 2 |
|
Source
|
Homo sapiens (Human) (4EBP1_HUMAN) |
|
|
Sequence
|
A: |
GPHMLEAEHPLQYNYTFWYSRNIKQIGTFASVEQFWRFYS
HMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRL
RKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDI
ISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTD
SIKMP
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
93 |
| type |
|
| sequence |
Q
|
| description |
binding site for residue FMT A 301
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
96 |
| type |
|
| sequence |
R
|
| description |
binding site for residue FMT A 301
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
174 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
112-135 |
| type |
prosite |
| sequence |
DFHLFKEGIKPMWEDDANKNGGKW
|
| description |
IF4E Eukaryotic initiation factor 4E signature. DFhlFKegIkPmWEDdanknGGKW
|
| source |
prosite : PS00813
|
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|
|