eF-site/Summary 5ecg-A

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Title	Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)
Classification	ANTITUMOR PROTEIN
Compound	Cellular tumor antigen p53
Source	Homo sapiens (Human) (5ECG)

Sequence	A:	SVPSQKTYQGSYGFRLGFLHSSVTCTYSPALNKMFCQLAK TCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHH ERCSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYE PPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSS GNLLGRNSFEVRVCACPGRDRRTEEENLRKKG

Description

Functional site


1)	chain	A
	residue	176
	type
	sequence	C
	description	binding site for residue ZN A 401
	source	: AC1

2)	chain	A
	residue	179
	type
	sequence	H
	description	binding site for residue ZN A 401
	source	: AC1

3)	chain	A
	residue	238
	type
	sequence	C
	description	binding site for residue ZN A 401
	source	: AC1

4)	chain	A
	residue	242
	type
	sequence	C
	description	binding site for residue ZN A 401
	source	: AC1

5)	chain	A
	residue	237-249
	type	prosite
	sequence	MCNSSCMGGMNRR
	description	P53 p53 family signature. MCNSSCMGGMNRR
	source	prosite : PS00348

6)	chain	A
	residue	238
	type	MOD_RES
	sequence	C
	description	Phosphoserine => ECO:0000269\|PubMed:19176521, ECO:0000269\|PubMed:21144835
	source	Swiss-Prot : SWS_FT_FI2

7)	chain	A
	residue	242
	type	MOD_RES
	sequence	C
	description	Phosphoserine => ECO:0000269\|PubMed:19176521, ECO:0000269\|PubMed:21144835
	source	Swiss-Prot : SWS_FT_FI2

8)	chain	A
	residue	269
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by AURKB => ECO:0000269\|PubMed:20959462
	source	Swiss-Prot : SWS_FT_FI5

9)	chain	A
	residue	284
	type	MOD_RES
	sequence	T
	description	Phosphothreonine; by AURKB => ECO:0000269\|PubMed:20959462
	source	Swiss-Prot : SWS_FT_FI6

10)	chain	A
	residue	291
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:19536131
	source	Swiss-Prot : SWS_FT_FI8

11)	chain	A
	residue	292
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:19536131
	source	Swiss-Prot : SWS_FT_FI8