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5ECG

Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)

Summary for 5ECG
Entry DOI10.2210/pdb5ecg/pdb
DescriptorCellular tumor antigen p53, Tumor suppressor p53-binding protein 1, SEP-GLN-GLU-TYR, ... (5 entities in total)
Functional Keywordsdna repair, nhej, h2ax, brct, antitumor protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Nucleus: Q12888
Total number of polymer chains6
Total formula weight110952.06
Authors
Day, M.,Oliver, A.W.,Pearl, L.H. (deposition date: 2015-10-20, release date: 2015-12-16, Last modification date: 2024-01-10)
Primary citationBaldock, R.A.,Day, M.,Wilkinson, O.J.,Cloney, R.,Jeggo, P.A.,Oliver, A.W.,Watts, F.Z.,Pearl, L.H.
ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX.
Cell Rep, 13:2081-2089, 2015
Cited by
PubMed: 26628370
DOI: 10.1016/j.celrep.2015.10.074
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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