eF-site ID 5a7w-B PDB Code 5a7w Chain B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 35 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence B:  LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKV VPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNI QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGIT IEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKS WYSVPPEHGKRLERLAKGFFPGSAESCEAFLRHKMTLISP LMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAE STNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPE RYKLWKAGKDNTVIDHTLPTPEAAEF Description Functional site 1) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC1 2) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 3) chain B residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 4) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 5) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 6) chain B residue 86 type sequence N description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 7) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 8) chain B residue 135 type sequence D description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 9) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 10) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 11) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 12) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 13) chain B residue 198 type sequence N description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 14) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 15) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 16) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE 35M B 1355 source : AC3 17) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 1356 source : AC6 18) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 1356 source : AC6 19) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 1356 source : AC6 20) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 21) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 22) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 23) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 24) chain B residue 224 type sequence K description BINDING SITE FOR RESIDUE EDO B 1358 source : AC9 25) chain B residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO B 1358 source : AC9 26) chain B residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO B 1358 source : AC9 27) chain B residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO B 1358 source : AC9 28) chain B residue 114 type sequence F description BINDING SITE FOR RESIDUE EDO B 1359 source : BC1 29) chain B residue 261 type sequence T description BINDING SITE FOR RESIDUE EDO B 1359 source : BC1 30) chain B residue 281 type sequence H description BINDING SITE FOR RESIDUE EDO B 1359 source : BC1 31) chain B residue 83 type sequence T description BINDING SITE FOR RESIDUE EDO B 1360 source : BC2 32) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE EDO B 1360 source : BC2 33) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE EDO B 1360 source : BC2 34) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE EDO B 1360 source : BC2 35) chain B residue 243 type sequence T description BINDING SITE FOR RESIDUE EDO B 1360 source : BC2 36) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE DMS B 1361 source : BC5 37) chain B residue 175 type sequence Y description BINDING SITE FOR RESIDUE DMS B 1361 source : BC5 38) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE DMS B 1361 source : BC5 39) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE DMS B 1361 source : BC5 40) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE DMS B 1361 source : BC5 41) chain B residue 290 type sequence N description BINDING SITE FOR RESIDUE DMS B 1361 source : BC5 42) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 43) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 44) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 45) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 46) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 47) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 48) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 54) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 55) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 56) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 57) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 58) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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