5A7W

Crystal structure of human JMJD2A in complex with compound 35

Summary for 5A7W

• Entry DOI: 10.2210/pdb5a7w/pdb
• Related: 5A7N 5A7O 5A7P 5A7Q 5A7S 5A80
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 4A, SULFATE ION, 2-[5-[(4-hydroxyphenyl)carbonylamino]-2-oxidanyl-phenyl]pyridine-4-carboxylic acid, ... (9 entities in total)
• Functional Keywords: oxidoreductase, kdm4a
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus : O75164 O75164
• Total number of polymer chains: 2
• Total formula weight: 90253.61

Authors

Nowak, R.,Velupillai, S.,Krojer, T.,Gileadi, C.,Johansson, C.,Korczynska, M.,Le, D.D.,Younger, N.,Gregori-Puigjane, E.,Tumber, A.,Iwasa, E.,Pollock, S.B.,Ortiz Torres, I.,Kopec, J.,Tallant, C.,Froese, S.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Shoichet, B.K.,Fujimori, D.G.,Oppermann, U. (deposition date: 2015-07-10, release date: 2016-01-13, Last modification date: 2024-01-10)

• Primary citation: Korczynska, M.,Le, D.D.,Younger, N.,Gregori-Puigjane, E.,Tumber, A.,Krojer, T.,Velupillai, S.,Gileadi, C.,Nowak, R.P.,Iwasa, E.,Pollock, S.B.,Ortiz Torres, I.,Oppermann, U.,Shoichet, B.K.,Fujimori, D.G.; Docking and Linking of Fragments to Discover Jumonji Histone Demethylase Inhibitors.; J.Med.Chem., 59:1580-, 2016; PubMed: 26699912; DOI: 10.1021/ACS.JMEDCHEM.5B01527

Experimental method

X-RAY DIFFRACTION (2.27 Å)