|
eF-site ID
|
5a63-D |
PDB Code
|
5a63 |
Chain
|
D |
|
click to enlarge
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Title
|
Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. |
Classification
|
HYDROLASE |
Compound
|
Nicastrin |
Source
|
(PEN2_HUMAN) |
|
Sequence
|
D: |
NLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREA
FLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIY
RPRWGALGDYLSFTIPLGTP
|
|
Description
|
(1) |
NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
|
|
Functional site
|
|
1)
|
chain |
D |
residue |
37-57 |
type |
TOPO_DOM |
sequence |
FFREAFLVPAYTEQSQIKGYV
|
description |
Cytoplasmic => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
D |
residue |
18-36 |
type |
INTRAMEM |
sequence |
YYLGGFAFLPFLWLVNIFW
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
3)
|
chain |
D |
residue |
58-78 |
type |
TRANSMEM |
sequence |
WRSAVGFLFWVIVLTSWITIF
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
4)
|
chain |
D |
residue |
79-101 |
type |
TOPO_DOM |
sequence |
QIYRPRWGALGDYLSFTIPLGTP
|
description |
Lumenal => ECO:0000269|PubMed:26280335, ECO:0000305|PubMed:12639958
|
source |
Swiss-Prot : SWS_FT_FI4
|
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|