eF-site ID 5a63-A PDB Code 5a63 Chain A click to enlarge Title Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. Classification HYDROLASE Compound Nicastrin Source (PEN2_HUMAN) Sequence A:  NSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVI HVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKG RTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYG PEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIK QCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRR SSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKPDD RVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQ KAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFP VQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQ VEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRA RNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSP EEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQA DPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQH YIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVP SENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSP AFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITL TVGFGILIFSLIVTYCINAKADVLF Description (1)  NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2 Functional site 1) chain A residue 187 type TOPO_DOM sequence N description Lumenal => ECO:0000269|PubMed:26280335, ECO:0000305|PubMed:12639958 source Swiss-Prot : SWS_FT_FI4 2) chain A residue 264 type TRANSMEM sequence N description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 3) chain A residue 435 type TRANSMEM sequence N description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 4) chain A residue 464 type TRANSMEM sequence N description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 5) chain A residue 506 type TRANSMEM sequence N description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 6) chain A residue 530 type TRANSMEM sequence N description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 7) chain A residue 562 type TRANSMEM sequence N description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 8) chain A residue 573 type TRANSMEM sequence N description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 9) chain A residue 417 type TRANSMEM sequence N description Helical; Name=4 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI6 10) chain A residue 277-291 type prosite sequence VAATRLDSRSFFWNV description WD_REPEATS_1 Trp-Asp (WD) repeats signature. VAATrlDsRSFFWNV source prosite : PS00678

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