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eF-site ID
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5a63-D |
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PDB Code
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5a63 |
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Chain
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D |
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click to enlarge
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Title
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Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. |
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Classification
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HYDROLASE |
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Compound
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Nicastrin |
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Source
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(PEN2_HUMAN) |
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Sequence
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D: |
NLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREA
FLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIY
RPRWGALGDYLSFTIPLGTP
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Description
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(1) |
NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
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Functional site
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1)
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chain |
D |
| residue |
37-57 |
| type |
TOPO_DOM |
| sequence |
FFREAFLVPAYTEQSQIKGYV
|
| description |
Cytoplasmic => ECO:0000269|PubMed:26280335
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
D |
| residue |
18-36 |
| type |
INTRAMEM |
| sequence |
YYLGGFAFLPFLWLVNIFW
|
| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI2
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3)
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chain |
D |
| residue |
58-78 |
| type |
TRANSMEM |
| sequence |
WRSAVGFLFWVIVLTSWITIF
|
| description |
Helical => ECO:0000269|PubMed:26280335
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| source |
Swiss-Prot : SWS_FT_FI3
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4)
|
chain |
D |
| residue |
79-101 |
| type |
TOPO_DOM |
| sequence |
QIYRPRWGALGDYLSFTIPLGTP
|
| description |
Lumenal => ECO:0000269|PubMed:26280335, ECO:0000305|PubMed:12639958
|
| source |
Swiss-Prot : SWS_FT_FI4
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