eF-site ID 5a63-B
PDB Code 5a63
Chain B

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Title Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.
Classification HYDROLASE
Compound Nicastrin
Source (PEN2_HUMAN)
Sequence B:  GAKHVIMLFVPVTLCMVVVVATIKSVSFYTRIISSLLLLF
FFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHW
KGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISV
YDLVAVVKLGLGDFIFYSVLVGKASATASGDWNTTIACFV
AILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYL
VQPFMDQLAFHQFYI
Description (1)  NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2


Functional site

1) chain B
residue 429-432
type TOPO_DOM
sequence KKAL
description Cytoplasmic => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 167-189
type INTRAMEM
sequence IISSLLLLFFFSFIYLGEVFKTY
description Helical => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI2

3) chain B
residue 195-216
type INTRAMEM
sequence YITVALLIWNFGVVGMISIHWK
description Helical => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI2

4) chain B
residue 221-241
type INTRAMEM
sequence LQQAYLIMISALMALVFIKYL
description Helical => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI2

5) chain B
residue 381-401
type INTRAMEM
sequence LGLGDFIFYSVLVGKASATAS
description Helical => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI2

6) chain B
residue 408-428
type INTRAMEM
sequence IACFVAILIGLCLTLLLLAIF
description Helical => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI2

7) chain B
residue 433-453
type INTRAMEM
sequence PALPISITFGLVFYFATDYLV
description Helical => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI2

8) chain B
residue 454-467
type TRANSMEM
sequence QPFMDQLAFHQFYI
description Helical => ECO:0000269|PubMed:26280335
source Swiss-Prot : SWS_FT_FI3


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