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eF-site ID
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5a63-B |
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PDB Code
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5a63 |
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Chain
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B |
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click to enlarge
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Title
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Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. |
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Classification
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HYDROLASE |
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Compound
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Nicastrin |
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Source
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(PEN2_HUMAN) |
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Sequence
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B: |
GAKHVIMLFVPVTLCMVVVVATIKSVSFYTRIISSLLLLF
FFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHW
KGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISV
YDLVAVVKLGLGDFIFYSVLVGKASATASGDWNTTIACFV
AILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYL
VQPFMDQLAFHQFYI
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Description
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(1) |
NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
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Functional site
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1)
|
chain |
B |
| residue |
429-432 |
| type |
TOPO_DOM |
| sequence |
KKAL
|
| description |
Cytoplasmic => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
B |
| residue |
167-189 |
| type |
INTRAMEM |
| sequence |
IISSLLLLFFFSFIYLGEVFKTY
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| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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3)
|
chain |
B |
| residue |
195-216 |
| type |
INTRAMEM |
| sequence |
YITVALLIWNFGVVGMISIHWK
|
| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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4)
|
chain |
B |
| residue |
221-241 |
| type |
INTRAMEM |
| sequence |
LQQAYLIMISALMALVFIKYL
|
| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
B |
| residue |
381-401 |
| type |
INTRAMEM |
| sequence |
LGLGDFIFYSVLVGKASATAS
|
| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
B |
| residue |
408-428 |
| type |
INTRAMEM |
| sequence |
IACFVAILIGLCLTLLLLAIF
|
| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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7)
|
chain |
B |
| residue |
433-453 |
| type |
INTRAMEM |
| sequence |
PALPISITFGLVFYFATDYLV
|
| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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8)
|
chain |
B |
| residue |
454-467 |
| type |
TRANSMEM |
| sequence |
QPFMDQLAFHQFYI
|
| description |
Helical => ECO:0000269|PubMed:26280335
|
| source |
Swiss-Prot : SWS_FT_FI3
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