|
eF-site ID
|
5a63-B |
PDB Code
|
5a63 |
Chain
|
B |
|
click to enlarge
|
|
Title
|
Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. |
Classification
|
HYDROLASE |
Compound
|
Nicastrin |
Source
|
(PEN2_HUMAN) |
|
Sequence
|
B: |
GAKHVIMLFVPVTLCMVVVVATIKSVSFYTRIISSLLLLF
FFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHW
KGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISV
YDLVAVVKLGLGDFIFYSVLVGKASATASGDWNTTIACFV
AILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYL
VQPFMDQLAFHQFYI
|
|
Description
|
(1) |
NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
429-432 |
type |
TOPO_DOM |
sequence |
KKAL
|
description |
Cytoplasmic => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
B |
residue |
167-189 |
type |
INTRAMEM |
sequence |
IISSLLLLFFFSFIYLGEVFKTY
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
3)
|
chain |
B |
residue |
195-216 |
type |
INTRAMEM |
sequence |
YITVALLIWNFGVVGMISIHWK
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
B |
residue |
221-241 |
type |
INTRAMEM |
sequence |
LQQAYLIMISALMALVFIKYL
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
B |
residue |
381-401 |
type |
INTRAMEM |
sequence |
LGLGDFIFYSVLVGKASATAS
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
6)
|
chain |
B |
residue |
408-428 |
type |
INTRAMEM |
sequence |
IACFVAILIGLCLTLLLLAIF
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
7)
|
chain |
B |
residue |
433-453 |
type |
INTRAMEM |
sequence |
PALPISITFGLVFYFATDYLV
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
8)
|
chain |
B |
residue |
454-467 |
type |
TRANSMEM |
sequence |
QPFMDQLAFHQFYI
|
description |
Helical => ECO:0000269|PubMed:26280335
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|