eF-site ID 4zn9-B PDB Code 4zn9 Chain B click to enlarge Title Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Oxabicyclic Heptene Sulfonate (OBHS) Classification TRANSCRIPTION Compound Estrogen receptor Source Homo sapiens (Human) (NCOA2_HUMAN) Sequence B:  SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMG LLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWL EILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEI FDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGDHIHRVL DKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN KGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTS Description Functional site 1) chain B residue 347 type sequence T description binding site for residue OBH B 601 source : AC2 2) chain B residue 350 type sequence A description binding site for residue OBH B 601 source : AC2 3) chain B residue 353 type sequence E description binding site for residue OBH B 601 source : AC2 4) chain B residue 387 type sequence L description binding site for residue OBH B 601 source : AC2 5) chain B residue 388 type sequence M description binding site for residue OBH B 601 source : AC2 6) chain B residue 394 type sequence R description binding site for residue OBH B 601 source : AC2 7) chain B residue 404 type sequence F description binding site for residue OBH B 601 source : AC2 8) chain B residue 421 type sequence M description binding site for residue OBH B 601 source : AC2 9) chain B residue 424 type sequence I description binding site for residue OBH B 601 source : AC2 10) chain B residue 521 type sequence G description binding site for residue OBH B 601 source : AC2 11) chain B residue 524 type sequence H description binding site for residue OBH B 601 source : AC2 12) chain B residue 525 type sequence L description binding site for residue OBH B 601 source : AC2 13) chain B residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 14) chain B residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 15) chain B residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 16) chain B residue 537 type MOD_RES sequence S description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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