4ZN9

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Oxabicyclic Heptene Sulfonate (OBHS)

Summary for 4ZN9

Entry DOI	10.2210/pdb4zn9/pdb
Related	4PP6 4ZN7 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW
Descriptor	Estrogen receptor, Nuclear receptor-interacting peptide, cyclohexa-2,5-dien-1-yl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, ... (4 entities in total)
Functional Keywords	protein ligand complex, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	62695.63
Authors	Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Cavett, V.,Nowak, J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. (deposition date: 2015-05-04, release date: 2015-09-09, Last modification date: 2024-03-06)
Primary citation	Zheng, Y.,Zhu, M.,Srinivasan, S.,Nwachukwu, J.C.,Cavett, V.,Min, J.,Carlson, K.E.,Wang, P.,Dong, C.,Katzenellenbogen, J.A.,Nettles, K.W.,Zhou, H.B. Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands. Chemmedchem, 7:1094-1100, 2012 Cited by PubMed: 22517684 DOI: 10.1002/cmdc.201200048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.215 Å)

Structure validation