eF-site ID 4wur-AB PDB Code 4wur Chain A, B click to enlarge Title The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin Classification HYDROLASE Compound Papain-like protease Source Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) (UBB_HUMAN) Sequence A:  TIEVLVTVDGVNFRTVVLNNKNTYRSQLGCVFFNGADISD TIPDEKQNGHSLYLADNLTADETKALKELYGPVDPTFLHR FYSLKAAVHGWKMVVCDKVRSLKLSDNNSYLNAVIMTLDL LKDIKFVIPALQHAFMKHKGGDSTDFIALIMAYGNCTFGA PDDASRLLHTVLAKAELCCSARMVWREWCNVCGIKDVVLQ GLKACCYVGVQTVEDLRARMTYVCQCGGERHRQLVEHTTP WLLLSGTPNEKLVTTSTAPDFVAFNVFQGIETAVGHYVHA RLKGGLILKFDSGTVSKTSDWKCKVTDVLFPGQKYSS B:  IFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR LIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain A residue 91 type sequence H description binding site for residue IPA A 401 source : AC1 2) chain A residue 93 type sequence W description binding site for residue IPA A 401 source : AC1 3) chain A residue 145 type sequence S description binding site for residue IPA A 401 source : AC1 4) chain A residue 146 type sequence T description binding site for residue IPA A 401 source : AC1 5) chain A residue 149 type sequence I description binding site for residue IPA A 401 source : AC1 6) chain A residue 84 type sequence Y description binding site for residue IPA A 402 source : AC2 7) chain A residue 87 type sequence K description binding site for residue IPA A 402 source : AC2 8) chain A residue 191 type sequence C description binding site for residue ZN A 403 source : AC3 9) chain A residue 194 type sequence C description binding site for residue ZN A 403 source : AC3 10) chain A residue 226 type sequence C description binding site for residue ZN A 403 source : AC3 11) chain A residue 228 type sequence C description binding site for residue ZN A 403 source : AC3 12) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 13) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 14) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 15) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 16) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 17) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 18) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 19) chain A residue 278 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 20) chain A residue 293 type SITE sequence D description Essential for function source Swiss-Prot : SWS_FT_FI2 21) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 194 type MOD_RES sequence C description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 226 type MOD_RES sequence C description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 228 type MOD_RES sequence C description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000269|PubMed:28525742 source Swiss-Prot : SWS_FT_FI5 27) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 28) chain B residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI7 29) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 30) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 31) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

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