eF-site ID 4wur-A
PDB Code 4wur
Chain A

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Title The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin
Classification HYDROLASE
Compound Papain-like protease
Source Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) (UBB_HUMAN)
Sequence A:  TIEVLVTVDGVNFRTVVLNNKNTYRSQLGCVFFNGADISD
TIPDEKQNGHSLYLADNLTADETKALKELYGPVDPTFLHR
FYSLKAAVHGWKMVVCDKVRSLKLSDNNSYLNAVIMTLDL
LKDIKFVIPALQHAFMKHKGGDSTDFIALIMAYGNCTFGA
PDDASRLLHTVLAKAELCCSARMVWREWCNVCGIKDVVLQ
GLKACCYVGVQTVEDLRARMTYVCQCGGERHRQLVEHTTP
WLLLSGTPNEKLVTTSTAPDFVAFNVFQGIETAVGHYVHA
RLKGGLILKFDSGTVSKTSDWKCKVTDVLFPGQKYSS
Description


Functional site
1) chain A
residue 91
type
sequence H
description binding site for residue IPA A 401
source : AC1
2) chain A
residue 93
type
sequence W
description binding site for residue IPA A 401
source : AC1
3) chain A
residue 145
type
sequence S
description binding site for residue IPA A 401
source : AC1
4) chain A
residue 146
type
sequence T
description binding site for residue IPA A 401
source : AC1
5) chain A
residue 149
type
sequence I
description binding site for residue IPA A 401
source : AC1
6) chain A
residue 84
type
sequence Y
description binding site for residue IPA A 402
source : AC2
7) chain A
residue 87
type
sequence K
description binding site for residue IPA A 402
source : AC2
8) chain A
residue 191
type
sequence C
description binding site for residue ZN A 403
source : AC3
9) chain A
residue 194
type
sequence C
description binding site for residue ZN A 403
source : AC3
10) chain A
residue 226
type
sequence C
description binding site for residue ZN A 403
source : AC3
11) chain A
residue 228
type
sequence C
description binding site for residue ZN A 403
source : AC3
12) chain A
residue 194
type MOD_RES
sequence C
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3
13) chain A
residue 226
type MOD_RES
sequence C
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3
14) chain A
residue 228
type MOD_RES
sequence C
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3
15) chain A
residue 278
type SITE
sequence H
description Essential for function
source Swiss-Prot : SWS_FT_FI2
16) chain A
residue 293
type SITE
sequence D
description Essential for function
source Swiss-Prot : SWS_FT_FI2

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