eF-site ID 4rwv-A
PDB Code 4rwv
Chain A

click to enlarge
Title Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution
Classification TRANSCRIPTION
Compound Nuclear receptor subfamily 5 group A member 2
Source Homo sapiens (Human) (F1D8P4_HUMAN)
Sequence A:  SPASIPHLILELLKXEPDEPQVQAKIMAYLQQEQANRSKH
EKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMK
LLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSII
ASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVL
FSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKF
GQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEML
HAK
Description


Functional site

1) chain A
residue 342
type
sequence F
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

2) chain A
residue 416
type
sequence I
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

3) chain A
residue 419
type
sequence Q
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

4) chain A
residue 420
type
sequence A
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

5) chain A
residue 421
type
sequence G
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

6) chain A
residue 422
type
sequence A
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

7) chain A
residue 423
type
sequence T
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

8) chain A
residue 424
type
sequence L
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

9) chain A
residue 513
type
sequence A
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

10) chain A
residue 516
type
sequence Y
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

11) chain A
residue 520
type
sequence K
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

12) chain A
residue 537
type
sequence H
description BINDING SITE FOR RESIDUE PIZ A 601
source : AC1

13) chain A
residue 323
type
sequence M
description BINDING SITE FOR RESIDUE EDO A 602
source : AC2

14) chain A
residue 326
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 602
source : AC2

15) chain A
residue 409
type
sequence Q
description BINDING SITE FOR RESIDUE EDO A 602
source : AC2

16) chain A
residue 518
type
sequence Y
description BINDING SITE FOR RESIDUE EDO A 602
source : AC2

17) chain A
residue 519
type
sequence Y
description BINDING SITE FOR RESIDUE EDO A 602
source : AC2

18) chain A
residue 522
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 602
source : AC2

19) chain A
residue 426
type
sequence N
description BINDING SITE FOR RESIDUE EDO A 603
source : AC3

20) chain A
residue 430
type
sequence H
description BINDING SITE FOR RESIDUE EDO A 603
source : AC3

21) chain A
residue 508
type
sequence A
description BINDING SITE FOR RESIDUE EDO A 603
source : AC3

22) chain A
residue 512
type
sequence Q
description BINDING SITE FOR RESIDUE EDO A 603
source : AC3

23) chain A
residue 298
type
sequence P
description BINDING SITE FOR RESIDUE EDO A 604
source : AC4

24) chain A
residue 444
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 604
source : AC4

25) chain A
residue 446
type
sequence R
description BINDING SITE FOR RESIDUE EDO A 604
source : AC4

26) chain A
residue 489
type
sequence Y
description BINDING SITE FOR RESIDUE EDO A 604
source : AC4

27) chain A
residue 370
type
sequence K
description BINDING SITE FOR RESIDUE EDO A 605
source : AC5

28) chain A
residue 372
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 605
source : AC5

29) chain A
residue 429
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 605
source : AC5

30) chain A
residue 430
type
sequence H
description BINDING SITE FOR RESIDUE EDO A 605
source : AC5

31) chain A
residue 474
type
sequence Q
description BINDING SITE FOR RESIDUE EDO A 606
source : AC6

32) chain A
residue 478
type
sequence N
description BINDING SITE FOR RESIDUE EDO A 606
source : AC6

33) chain A
residue 503
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 606
source : AC6

34) chain A
residue 376-447
type DNA_BIND
sequence KLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSI
IASQAGATLNNLMSHAQELVAKLRSLQFDQRE
description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 379-399
type ZN_FING
sequence QNCWSELLILDHIYRQVVHGK
description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407
source Swiss-Prot : SWS_FT_FI2

36) chain A
residue 415-439
type ZN_FING
sequence IIASQAGATLNNLMSHAQELVAKLR
description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407
source Swiss-Prot : SWS_FT_FI2


Display surface

Download
Links