4RWV

Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution

Summary for 4RWV

• Entry DOI: 10.2210/pdb4rwv/pdb
• Descriptor: Nuclear receptor subfamily 5 group A member 2, Nuclear receptor DAX1, (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate, ... (6 entities in total)
• Functional Keywords: ligand-binding domain of nuclear hormone receptor, pf00104 family, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-biology, partnership for stem cell biology, transcription, stemcell
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : O00482 F1D8P4
• Total number of polymer chains: 2
• Total formula weight: 31868.46

Authors

Joint Center for Structural Genomics (JCSG),Partnership for Stem Cell Biology,Partnership for Stem Cell Biology (STEMCELL) (deposition date: 2014-12-05, release date: 2015-01-21, Last modification date: 2023-12-06)

• Primary citation: Joint Center for Structural Genomics (JCSG),Partnership for Stem Cell Biology; Crystal structure of a Homo sapiens hepatocytic transcription factor hB1F-2 (B1F2) in complex with nuclear receptor subfamily 0 group B member 1 (NR0B1, residues 140-154) from human at 1.86 A resolution; To be published,

Experimental method

X-RAY DIFFRACTION (1.859 Å)