eF-site ID 4r8q-A
PDB Code 4r8q
Chain A

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Title Structure and substrate recruitment of the human spindle checkpoint kinase bub1
Classification TRANSFERASE
Compound Mitotic checkpoint serine/threonine-protein kinase BUB1
Source Homo sapiens (Human) (BUB1_HUMAN)
Sequence A:  FIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIK
PKTEFQLGSKLVYVHHLLGEGAFAQVYEATQQKFVLKVQK
PANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVL
VGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYM
IEQVHDCEIIHGDIKPDNFILGNGFLESAGLALIDLGQSI
DMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGV
AATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEF
FHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRN
RLIVLLLECKRS
Description


Functional site

1) chain A
residue 794
type
sequence G
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

2) chain A
residue 796
type
sequence G
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

3) chain A
residue 797
type
sequence A
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

4) chain A
residue 798
type
sequence F
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

5) chain A
residue 799
type
sequence A
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

6) chain A
residue 801
type
sequence V
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

7) chain A
residue 821
type
sequence K
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

8) chain A
residue 850
type
sequence M
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

9) chain A
residue 867
type
sequence E
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

10) chain A
residue 869
type
sequence Y
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

11) chain A
residue 873
type
sequence T
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

12) chain A
residue 921
type
sequence D
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

13) chain A
residue 922
type
sequence N
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

14) chain A
residue 946
type
sequence D
description BINDING SITE FOR RESIDUE ADP A 1501
source : AC1

15) chain A
residue 922
type
sequence N
description BINDING SITE FOR RESIDUE MG A 1502
source : AC2

16) chain A
residue 946
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1502
source : AC2

17) chain A
residue 946
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1503
source : AC3

18) chain A
residue 793-821
type prosite
sequence LGEGAFAQVYEATQQKFVLK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFAQVYeAtqgdlndaknkqk.....FVLK
source prosite : PS00107

19) chain A
residue 913-925
type prosite
sequence IIHGDIKPDNFIL
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHgDIKpdNFIL
source prosite : PS00108

20) chain A
residue 917
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 793
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 821
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2


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