eF-site ID 4r8q-A PDB Code 4r8q Chain A click to enlarge Title Structure and substrate recruitment of the human spindle checkpoint kinase bub1 Classification TRANSFERASE Compound Mitotic checkpoint serine/threonine-protein kinase BUB1 Source Homo sapiens (Human) (BUB1_HUMAN) Sequence A:  FIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIK PKTEFQLGSKLVYVHHLLGEGAFAQVYEATQQKFVLKVQK PANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVL VGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYM IEQVHDCEIIHGDIKPDNFILGNGFLESAGLALIDLGQSI DMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGV AATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEF FHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRN RLIVLLLECKRS Description Functional site 1) chain A residue 794 type sequence G description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 2) chain A residue 796 type sequence G description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 3) chain A residue 797 type sequence A description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 4) chain A residue 798 type sequence F description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 5) chain A residue 799 type sequence A description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 6) chain A residue 801 type sequence V description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 7) chain A residue 821 type sequence K description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 8) chain A residue 850 type sequence M description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 9) chain A residue 867 type sequence E description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 10) chain A residue 869 type sequence Y description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 11) chain A residue 873 type sequence T description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 12) chain A residue 921 type sequence D description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 13) chain A residue 922 type sequence N description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 14) chain A residue 946 type sequence D description BINDING SITE FOR RESIDUE ADP A 1501 source : AC1 15) chain A residue 922 type sequence N description BINDING SITE FOR RESIDUE MG A 1502 source : AC2 16) chain A residue 946 type sequence D description BINDING SITE FOR RESIDUE MG A 1502 source : AC2 17) chain A residue 946 type sequence D description BINDING SITE FOR RESIDUE MG A 1503 source : AC3 18) chain A residue 793-821 type prosite sequence LGEGAFAQVYEATQQKFVLK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFAQVYeAtqgdlndaknkqk.....FVLK source prosite : PS00107 19) chain A residue 913-925 type prosite sequence IIHGDIKPDNFIL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHgDIKpdNFIL source prosite : PS00108 20) chain A residue 917 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 793 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 821 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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