eF-site ID 4p38-B PDB Code 4p38 Chain B click to enlarge Title Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329 Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Compound Corticosteroid 11-beta-dehydrogenase isozyme 1 Source Homo sapiens (Human) (DHI1_HUMAN) Sequence B:  EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTA RSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQ AGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFL SYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSA SKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMK AVSIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTL LIRNPSRKILEELYSTSYNWDRF Description Functional site 1) chain B residue 280 type sequence Y description binding site for residue 21T A 302 source : AC2 2) chain B residue 284 type sequence Y description binding site for residue 21T A 302 source : AC2 3) chain B residue 41 type sequence G description binding site for residue NDP B 301 source : AC4 4) chain B residue 42 type sequence A description binding site for residue NDP B 301 source : AC4 5) chain B residue 43 type sequence S description binding site for residue NDP B 301 source : AC4 6) chain B residue 44 type sequence K description binding site for residue NDP B 301 source : AC4 7) chain B residue 45 type sequence G description binding site for residue NDP B 301 source : AC4 8) chain B residue 46 type sequence I description binding site for residue NDP B 301 source : AC4 9) chain B residue 65 type sequence A description binding site for residue NDP B 301 source : AC4 10) chain B residue 66 type sequence R description binding site for residue NDP B 301 source : AC4 11) chain B residue 67 type sequence S description binding site for residue NDP B 301 source : AC4 12) chain B residue 92 type sequence T description binding site for residue NDP B 301 source : AC4 13) chain B residue 93 type sequence M description binding site for residue NDP B 301 source : AC4 14) chain B residue 119 type sequence N description binding site for residue NDP B 301 source : AC4 15) chain B residue 120 type sequence H description binding site for residue NDP B 301 source : AC4 16) chain B residue 121 type sequence I description binding site for residue NDP B 301 source : AC4 17) chain B residue 168 type sequence V description binding site for residue NDP B 301 source : AC4 18) chain B residue 169 type sequence S description binding site for residue NDP B 301 source : AC4 19) chain B residue 170 type sequence S description binding site for residue NDP B 301 source : AC4 20) chain B residue 183 type sequence Y description binding site for residue NDP B 301 source : AC4 21) chain B residue 187 type sequence K description binding site for residue NDP B 301 source : AC4 22) chain B residue 215 type sequence L description binding site for residue NDP B 301 source : AC4 23) chain B residue 216 type sequence G description binding site for residue NDP B 301 source : AC4 24) chain B residue 217 type sequence L description binding site for residue NDP B 301 source : AC4 25) chain B residue 218 type sequence I description binding site for residue NDP B 301 source : AC4 26) chain B residue 220 type sequence T description binding site for residue NDP B 301 source : AC4 27) chain B residue 222 type sequence T description binding site for residue NDP B 301 source : AC4 28) chain B residue 223 type sequence A description binding site for residue NDP B 301 source : AC4 29) chain B residue 170 type sequence S description binding site for residue 21T B 302 source : AC5 30) chain B residue 171 type sequence L description binding site for residue 21T B 302 source : AC5 31) chain B residue 177 type sequence Y description binding site for residue 21T B 302 source : AC5 32) chain B residue 183 type sequence Y description binding site for residue 21T B 302 source : AC5 33) chain B residue 215 type sequence L description binding site for residue 21T B 302 source : AC5 34) chain B residue 216 type sequence G description binding site for residue 21T B 302 source : AC5 35) chain B residue 217 type sequence L description binding site for residue 21T B 302 source : AC5 36) chain B residue 45 type sequence G description binding site for residue CL B 303 source : AC6 37) chain B residue 221 type sequence E description binding site for residue CL B 303 source : AC6 38) chain B residue 238 type sequence K description binding site for residue CL B 303 source : AC6 39) chain B residue 218 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 41 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 92 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 119 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 183 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 183 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI1 45) chain B residue 207 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 46) chain B residue 170 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 source Swiss-Prot : SWS_FT_FI3 47) chain B residue 123 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI4 48) chain B residue 162 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI4

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