eF-site ID 4hw3-J
PDB Code 4hw3
Chain J

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Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
Classification APOPTOSIS/INHIBITOR
Compound Induced myeloid leukemia cell differentiation protein Mcl-1
Source Homo sapiens (Human) (MCL1_HUMAN)
Sequence J:  DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALE
TLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMI
HVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLA
ESITDVLVRTKRDWLVKQRGWDGFVEFFHV
Description


Functional site

1) chain J
residue 228
type
sequence F
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

2) chain J
residue 231
type
sequence M
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

3) chain J
residue 235
type
sequence L
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

4) chain J
residue 246
type
sequence L
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

5) chain J
residue 250
type
sequence M
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

6) chain J
residue 253
type
sequence V
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

7) chain J
residue 263
type
sequence R
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

8) chain J
residue 266
type
sequence T
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

9) chain J
residue 267
type
sequence L
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

10) chain J
residue 270
type
sequence F
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

11) chain J
residue 271
type
sequence G
description BINDING SITE FOR RESIDUE 19G J 400
source : BC1

12) chain J
residue 194
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1

13) chain J
residue 197
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1


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