eF-site ID 4hw3-J PDB Code 4hw3 Chain J click to enlarge Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Classification APOPTOSIS/INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source Homo sapiens (Human) (MCL1_HUMAN) Sequence J:  DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALE TLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMI HVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLA ESITDVLVRTKRDWLVKQRGWDGFVEFFHV Description Functional site 1) chain J residue 228 type sequence F description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 2) chain J residue 231 type sequence M description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 3) chain J residue 235 type sequence L description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 4) chain J residue 246 type sequence L description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 5) chain J residue 250 type sequence M description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 6) chain J residue 253 type sequence V description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 7) chain J residue 263 type sequence R description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 8) chain J residue 266 type sequence T description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 9) chain J residue 267 type sequence L description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 10) chain J residue 270 type sequence F description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 11) chain J residue 271 type sequence G description BINDING SITE FOR RESIDUE 19G J 400 source : BC1 12) chain J residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 13) chain J residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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