eF-site ID 4hw3-D PDB Code 4hw3 Chain D click to enlarge Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Classification APOPTOSIS/INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source Homo sapiens (Human) (MCL1_HUMAN) Sequence D:  GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKAL ETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVM IHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL AESITDVLVRTKRDWLVKQRGWDGFVEFFHVED Description Functional site 1) chain D residue 308 type sequence K description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 2) chain D residue 231 type sequence M description BINDING SITE FOR RESIDUE 19G D 400 source : AC4 3) chain D residue 253 type sequence V description BINDING SITE FOR RESIDUE 19G D 400 source : AC4 4) chain D residue 263 type sequence R description BINDING SITE FOR RESIDUE 19G D 400 source : AC4 5) chain D residue 267 type sequence L description BINDING SITE FOR RESIDUE 19G D 400 source : AC4 6) chain D residue 270 type sequence F description BINDING SITE FOR RESIDUE 19G D 400 source : AC4 7) chain D residue 294 type sequence I description BINDING SITE FOR RESIDUE 19G D 400 source : AC4 8) chain D residue 258 type sequence V description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 9) chain D residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 10) chain D residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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