eF-site ID 4hw3-C PDB Code 4hw3 Chain C click to enlarge Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Classification APOPTOSIS/INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source Homo sapiens (Human) (MCL1_HUMAN) Sequence C:  GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKAL ETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVM IHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL AESITDVLVRTKRDWLVKQRGWDGFVEFFH Description Functional site 1) chain C residue 228 type sequence F description BINDING SITE FOR RESIDUE 19G C 400 source : AC3 2) chain C residue 253 type sequence V description BINDING SITE FOR RESIDUE 19G C 400 source : AC3 3) chain C residue 263 type sequence R description BINDING SITE FOR RESIDUE 19G C 400 source : AC3 4) chain C residue 266 type sequence T description BINDING SITE FOR RESIDUE 19G C 400 source : AC3 5) chain C residue 267 type sequence L description BINDING SITE FOR RESIDUE 19G C 400 source : AC3 6) chain C residue 270 type sequence F description BINDING SITE FOR RESIDUE 19G C 400 source : AC3 7) chain C residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 8) chain C residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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