eF-site ID 4g0v-ABCDEF PDB Code 4g0v Chain A, B, C, D, E, F click to enlarge Title Human topoisomerase iibeta in complex with DNA and mitoxantrone Classification ISOMERASE/DNA/ISOMERASE INHIBITOR Compound DNA topoisomerase 2-beta Source Homo sapiens (Human) (4G0V) Sequence A:  KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGV IGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVG LQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLIN FIHHNWPSLLKHGFLEEFITDMERHRILFRYAGPEDDAAI TLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDK REVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSN NINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTG WACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTI QELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQ AEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDIL KEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPDF NYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSD LWKEDLAAFVEELDKVESQERED B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL LINFIHHNWPSLLKHGFLEEFIAKEAKEYFADMERHRILF RYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLK HLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLF TCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNL AQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLS TLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLIN GAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPN YKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTW TQVYKEQVLEPMLNGPALISDYKEYHTDTTVKFVVKMTEE KLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETV QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFI LEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQG PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS PSDLWKEDLAAFVEELDKVESQERED C:  AGCCGAGC D:  TGCAGCTCGGCT E:  AGCCGAGC F:  TGCAGCTCGGCT Description Functional site 1) chain A residue 503 type sequence R description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 2) chain A residue 504 type sequence G description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 3) chain A residue 505 type sequence K description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 4) chain A residue 506 type sequence I description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 5) chain A residue 520 type sequence N description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 6) chain A residue 522 type sequence E description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 7) chain A residue 778 type sequence Q description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 8) chain A residue 782 type sequence M description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 9) chain C residue 8 type sequence C description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 10) chain D residue 9 type sequence T description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 11) chain F residue 12 type sequence A description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 12) chain F residue 13 type sequence G description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 13) chain F residue 14 type sequence C description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 14) chain A residue 557 type sequence D description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 15) chain A residue 559 type sequence D description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 16) chain A residue 795 type sequence N description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 17) chain A residue 867 type sequence N description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 18) chain B residue 557 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC4 19) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC4 20) chain B residue 795 type sequence N description BINDING SITE FOR RESIDUE MG B 1302 source : AC5 21) chain B residue 867 type sequence N description BINDING SITE FOR RESIDUE MG B 1302 source : AC5 22) chain B residue 503 type sequence R description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 23) chain B residue 504 type sequence G description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 24) chain B residue 505 type sequence K description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 25) chain B residue 520 type sequence N description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 26) chain B residue 522 type sequence E description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 27) chain B residue 778 type sequence Q description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 28) chain D residue 12 type sequence A description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 29) chain D residue 13 type sequence G description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 30) chain D residue 14 type sequence C description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 31) chain E residue 8 type sequence C description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 32) chain F residue 9 type sequence T description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 33) chain A residue 475-483 type prosite sequence LTEGDSAKS description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS source prosite : PS00177 34) chain A residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 39) chain A residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 40) chain B residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 43) chain B residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 44) chain B residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 45) chain B residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 46) chain A residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 47) chain A residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 48) chain A residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 49) chain A residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 50) chain A residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 51) chain B residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 52) chain B residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 53) chain B residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 54) chain A residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 55) chain B residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 56) chain A residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 57) chain B residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 58) chain A residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 59) chain B residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 60) chain B residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 61) chain B residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 62) chain B residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 63) chain B residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 64) chain A residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 65) chain A residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 66) chain A residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 67) chain B residue 638 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI9

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