eF-site ID 4g0v-ABCDEF
PDB Code 4g0v
Chain A, B, C, D, E, F

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Title Human topoisomerase iibeta in complex with DNA and mitoxantrone
Classification ISOMERASE/DNA/ISOMERASE INHIBITOR
Compound DNA topoisomerase 2-beta
Source Homo sapiens (Human) (4G0V)
Sequence A:  KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGV
IGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVG
LQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLIN
FIHHNWPSLLKHGFLEEFITDMERHRILFRYAGPEDDAAI
TLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYNDFI
NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDK
REVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSN
NINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTG
WACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTI
QELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQ
AEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDIL
KEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPDF
NYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSD
LWKEDLAAFVEELDKVESQERED
B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG
LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK
IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL
LINFIHHNWPSLLKHGFLEEFIAKEAKEYFADMERHRILF
RYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLK
HLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLF
TCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNL
AQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLS
TLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLIN
GAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPN
YKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTW
TQVYKEQVLEPMLNGPALISDYKEYHTDTTVKFVVKMTEE
KLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETV
QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFI
LEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS
PSDLWKEDLAAFVEELDKVESQERED
C:  AGCCGAGC
D:  TGCAGCTCGGCT
E:  AGCCGAGC
F:  TGCAGCTCGGCT
Description


Functional site

1) chain A
residue 503
type
sequence R
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

2) chain A
residue 504
type
sequence G
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

3) chain A
residue 505
type
sequence K
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

4) chain A
residue 506
type
sequence I
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

5) chain A
residue 520
type
sequence N
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

6) chain A
residue 522
type
sequence E
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

7) chain A
residue 778
type
sequence Q
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

8) chain A
residue 782
type
sequence M
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

9) chain C
residue 8
type
sequence C
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

10) chain D
residue 9
type
sequence T
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

11) chain F
residue 12
type
sequence A
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

12) chain F
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

13) chain F
residue 14
type
sequence C
description BINDING SITE FOR RESIDUE MIX A 1301
source : AC1

14) chain A
residue 557
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1302
source : AC2

15) chain A
residue 559
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1302
source : AC2

16) chain A
residue 795
type
sequence N
description BINDING SITE FOR RESIDUE MG A 1303
source : AC3

17) chain A
residue 867
type
sequence N
description BINDING SITE FOR RESIDUE MG A 1303
source : AC3

18) chain B
residue 557
type
sequence D
description BINDING SITE FOR RESIDUE MG B 1301
source : AC4

19) chain B
residue 559
type
sequence D
description BINDING SITE FOR RESIDUE MG B 1301
source : AC4

20) chain B
residue 795
type
sequence N
description BINDING SITE FOR RESIDUE MG B 1302
source : AC5

21) chain B
residue 867
type
sequence N
description BINDING SITE FOR RESIDUE MG B 1302
source : AC5

22) chain B
residue 503
type
sequence R
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

23) chain B
residue 504
type
sequence G
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

24) chain B
residue 505
type
sequence K
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

25) chain B
residue 520
type
sequence N
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

26) chain B
residue 522
type
sequence E
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

27) chain B
residue 778
type
sequence Q
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

28) chain D
residue 12
type
sequence A
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

29) chain D
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

30) chain D
residue 14
type
sequence C
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

31) chain E
residue 8
type
sequence C
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

32) chain F
residue 9
type
sequence T
description BINDING SITE FOR RESIDUE MIX D 101
source : AC6

33) chain A
residue 475-483
type prosite
sequence LTEGDSAKS
description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS
source prosite : PS00177

34) chain A
residue 821
type ACT_SITE
sequence Y
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI1

35) chain B
residue 821
type ACT_SITE
sequence Y
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI1

36) chain A
residue 477
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI2

37) chain B
residue 477
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI2

38) chain A
residue 557
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

39) chain A
residue 559
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

40) chain B
residue 557
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

41) chain B
residue 559
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

42) chain A
residue 505
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

43) chain B
residue 678
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

44) chain B
residue 739
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

45) chain B
residue 947
type SITE
sequence W
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

46) chain A
residue 508
type SITE
sequence N
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

47) chain A
residue 677
type SITE
sequence R
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

48) chain A
residue 678
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

49) chain A
residue 739
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

50) chain A
residue 947
type SITE
sequence W
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

51) chain B
residue 505
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

52) chain B
residue 508
type SITE
sequence N
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

53) chain B
residue 677
type SITE
sequence R
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

54) chain A
residue 773
type SITE
sequence Y
description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI5

55) chain B
residue 773
type SITE
sequence Y
description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI5

56) chain A
residue 820
type SITE
sequence R
description Transition state stabilizer
source Swiss-Prot : SWS_FT_FI6

57) chain B
residue 820
type SITE
sequence R
description Transition state stabilizer
source Swiss-Prot : SWS_FT_FI6

58) chain A
residue 872
type SITE
sequence I
description Important for DNA bending; intercalates between base pairs of target DNA
source Swiss-Prot : SWS_FT_FI7

59) chain B
residue 872
type SITE
sequence I
description Important for DNA bending; intercalates between base pairs of target DNA
source Swiss-Prot : SWS_FT_FI7

60) chain B
residue 641
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

61) chain B
residue 671
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

62) chain B
residue 707
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

63) chain B
residue 1087
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

64) chain A
residue 671
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

65) chain A
residue 707
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

66) chain A
residue 1087
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

67) chain B
residue 638
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI9


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