eF-site ID 4g0v-AB PDB Code 4g0v Chain A, B click to enlarge Title Human topoisomerase iibeta in complex with DNA and mitoxantrone Classification ISOMERASE/DNA/ISOMERASE INHIBITOR Compound DNA topoisomerase 2-beta Source Homo sapiens (Human) (4G0V) Sequence A:  KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGV IGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVG LQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLIN FIHHNWPSLLKHGFLEEFITDMERHRILFRYAGPEDDAAI TLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDK REVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSN NINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTG WACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTI QELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQ AEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDIL KEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPDF NYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSD LWKEDLAAFVEELDKVESQERED B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL LINFIHHNWPSLLKHGFLEEFIAKEAKEYFADMERHRILF RYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLK HLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLF TCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNL AQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLS TLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLIN GAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPN YKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTW TQVYKEQVLEPMLNGPALISDYKEYHTDTTVKFVVKMTEE KLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETV QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFI LEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQG PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS PSDLWKEDLAAFVEELDKVESQERED Description Functional site 1) chain A residue 503 type sequence R description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 2) chain A residue 504 type sequence G description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 3) chain A residue 505 type sequence K description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 4) chain A residue 506 type sequence I description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 5) chain A residue 520 type sequence N description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 6) chain A residue 522 type sequence E description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 7) chain A residue 778 type sequence Q description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 8) chain A residue 782 type sequence M description BINDING SITE FOR RESIDUE MIX A 1301 source : AC1 9) chain A residue 557 type sequence D description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 10) chain A residue 559 type sequence D description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 11) chain A residue 795 type sequence N description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 12) chain A residue 867 type sequence N description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 13) chain B residue 557 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC4 14) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC4 15) chain B residue 795 type sequence N description BINDING SITE FOR RESIDUE MG B 1302 source : AC5 16) chain B residue 867 type sequence N description BINDING SITE FOR RESIDUE MG B 1302 source : AC5 17) chain B residue 503 type sequence R description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 18) chain B residue 504 type sequence G description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 19) chain B residue 505 type sequence K description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 20) chain B residue 520 type sequence N description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 21) chain B residue 522 type sequence E description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 22) chain B residue 778 type sequence Q description BINDING SITE FOR RESIDUE MIX D 101 source : AC6 23) chain A residue 475-483 type prosite sequence LTEGDSAKS description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS source prosite : PS00177 24) chain A residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 33) chain B residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 34) chain B residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 35) chain B residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 36) chain A residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 37) chain A residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 38) chain A residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 39) chain A residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 40) chain A residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 41) chain B residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 42) chain B residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 43) chain B residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 44) chain A residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 45) chain B residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 46) chain A residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 47) chain B residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 48) chain A residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 49) chain B residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 50) chain B residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 51) chain B residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 52) chain B residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 53) chain B residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 54) chain A residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 55) chain A residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 56) chain A residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 57) chain B residue 638 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI9

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