eF-site ID 4fjv-ABCD PDB Code 4fjv Chain A, B, C, D click to enlarge Title Crystal Structure of Human Otubain2 and Ubiquitin Complex Classification HYDROLASE Compound Ubiquitin thioesterase OTUB2 Source Homo sapiens (Human) (UBC_HUMAN) Sequence A:  SETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTA IRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQT PNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKV FNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIK DFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDT ALNHHVFPEAATPSVYLLYKTSHYNILYAAD B:  DVPDYAHMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDK EGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL RG C:  ETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAI RKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTP NDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVF NDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKD FCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTA LNHHVFPEAATPSVYLLYKTSHYNILYAAD D:  DVPDYAHMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDK EGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL RG Description Functional site 1) chain A residue 6 type sequence F description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 2) chain A residue 7 type sequence N description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 3) chain A residue 10 type sequence S description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 4) chain A residue 44 type sequence K description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 5) chain A residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 6) chain A residue 46 type sequence K description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 7) chain C residue 20 type sequence R description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 8) chain A residue 12 type sequence K description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 9) chain A residue 14 type sequence D description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 10) chain C residue 12 type sequence K description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 11) chain C residue 14 type sequence D description BINDING SITE FOR RESIDUE GOL A 302 source : AC2 12) chain A residue 196 type sequence V description BINDING SITE FOR RESIDUE GOL A 303 source : AC3 13) chain A residue 220 type sequence Y description BINDING SITE FOR RESIDUE GOL A 303 source : AC3 14) chain A residue 221 type sequence K description BINDING SITE FOR RESIDUE GOL A 303 source : AC3 15) chain A residue 223 type sequence S description BINDING SITE FOR RESIDUE GOL A 303 source : AC3 16) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE NEH B 101 source : AC4 17) chain A residue 51 type sequence C description BINDING SITE FOR RESIDUE NEH B 101 source : AC4 18) chain A residue 223 type sequence S description BINDING SITE FOR RESIDUE NEH B 101 source : AC4 19) chain B residue 75 type sequence G description BINDING SITE FOR RESIDUE NEH B 101 source : AC4 20) chain A residue 20 type sequence R description BINDING SITE FOR RESIDUE GOL C 301 source : AC5 21) chain C residue 6 type sequence F description BINDING SITE FOR RESIDUE GOL C 301 source : AC5 22) chain C residue 7 type sequence N description BINDING SITE FOR RESIDUE GOL C 301 source : AC5 23) chain C residue 10 type sequence S description BINDING SITE FOR RESIDUE GOL C 301 source : AC5 24) chain C residue 45 type sequence T description BINDING SITE FOR RESIDUE GOL C 301 source : AC5 25) chain A residue 10 type sequence S description BINDING SITE FOR RESIDUE GOL C 302 source : AC6 26) chain A residue 11 type sequence E description BINDING SITE FOR RESIDUE GOL C 302 source : AC6 27) chain C residue 10 type sequence S description BINDING SITE FOR RESIDUE GOL C 303 source : AC7 28) chain C residue 49 type sequence G description BINDING SITE FOR RESIDUE NEH D 101 source : AC8 29) chain C residue 51 type sequence C description BINDING SITE FOR RESIDUE NEH D 101 source : AC8 30) chain C residue 223 type sequence S description BINDING SITE FOR RESIDUE NEH D 101 source : AC8 31) chain C residue 224 type sequence H description BINDING SITE FOR RESIDUE NEH D 101 source : AC8 32) chain D residue 75 type sequence G description BINDING SITE FOR RESIDUE NEH D 101 source : AC8 33) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 34) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 35) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 36) chain D residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 37) chain D residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 38) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 39) chain D residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 40) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 41) chain D residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 42) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 43) chain D residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 44) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 45) chain D residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 46) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 47) chain D residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 48) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 49) chain D residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 50) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 51) chain D residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 52) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 53) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 54) chain D residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 55) chain D residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 56) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9 57) chain D residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

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