eF-site ID 4e5w-B PDB Code 4e5w Chain B click to enlarge Title JAK1 kinase (JH1 domain) in complex with compound 26 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase JAK1 Source Homo sapiens (Human) (JAK1_HUMAN) Sequence B:  VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQ VAVKSLKPNHIADLKKEIEILRNLYHENIVKYKGICTENG IKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGM DYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIEKE XXTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHE LLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKR LPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL Description (1)  Tyrosine-protein kinase JAK1 (E.C.2.7.10.2) Functional site 1) chain B residue 1097 type sequence G description BINDING SITE FOR RESIDUE PEG B 1201 source : AC2 2) chain B residue 1098 type sequence Q description BINDING SITE FOR RESIDUE PEG B 1201 source : AC2 3) chain B residue 881 type sequence L description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 4) chain B residue 882 type sequence G description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 5) chain B residue 883 type sequence E description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 6) chain B residue 884 type sequence G description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 7) chain B residue 889 type sequence V description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 8) chain B residue 906 type sequence A description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 9) chain B residue 957 type sequence E description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 10) chain B residue 958 type sequence F description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 11) chain B residue 959 type sequence L description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 12) chain B residue 1003 type sequence D description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 13) chain B residue 1007 type sequence R description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 14) chain B residue 1008 type sequence N description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 15) chain B residue 1010 type sequence L description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 16) chain B residue 1020 type sequence G description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 17) chain B residue 1021 type sequence D description BINDING SITE FOR RESIDUE 0NT B 1202 source : AC3 18) chain B residue 1003 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 881 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 908 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:32750333 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 1034 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 1035 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529 source Swiss-Prot : SWS_FT_FI4

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