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4E5W

JAK1 kinase (JH1 domain) in complex with compound 26

Summary for 4E5W
Entry DOI10.2210/pdb4e5w/pdb
Related4E4L 4E4M 4E4N 4E6D 4E6Q
DescriptorTyrosine-protein kinase JAK1, [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl][(2S)-1-(propan-2-yl)pyrrolidin-2-yl]methanone, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
Functional Keywordsjak1, kinase domain, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationEndomembrane system; Peripheral membrane protein: P23458
Total number of polymer chains2
Total formula weight70360.28
Authors
Murray, J.M. (deposition date: 2012-03-14, release date: 2012-05-30, Last modification date: 2012-07-11)
Primary citationKulagowski, J.J.,Blair, W.,Bull, R.J.,Chang, C.,Deshmukh, G.,Dyke, H.J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Harrison, T.K.,Hewitt, P.R.,Liimatta, M.,Hurley, C.A.,Johnson, A.,Johnson, T.,Kenny, J.R.,Bir Kohli, P.,Maxey, R.J.,Mendonca, R.,Mortara, K.,Murray, J.,Narukulla, R.,Shia, S.,Steffek, M.,Ubhayakar, S.,Ultsch, M.,van Abbema, A.,Ward, S.I.,Waszkowycz, B.,Zak, M.
Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.
J.Med.Chem., 55:5901-5921, 2012
Cited by
PubMed: 22591402
DOI: 10.1021/jm300438j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.86 Å)
Structure validation

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