eF-site ID 4aq7-AD PDB Code 4aq7 Chain A, D click to enlarge Title Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the aminoacylation conformation Classification LIGASE/RNA Compound LEUCINE--TRNA LIGASE Source Escherichia coli (strain K12) (4AQ7) Sequence A:  MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSM LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD AFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYD WSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCP NDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYAD ELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYD NTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAA FIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPV WAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVI LAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIA DKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDG TVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNG MPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANY WLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPA KQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGR IVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGAD TVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEH TAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQ TFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRM LNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDST LVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLD GVTVRKVIYVPGKLLNLVVG D:  MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSM LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD AFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYD WSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCP NDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYAD ELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYD NTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAA FIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPV WAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVI LAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIA DKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDG TVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNG MPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANY WLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPA KQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGR IVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGAD TVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEH TAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQ TFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRM LNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDST LVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLD GVTVRKVIYVPGKLLNLVVG Description Functional site 1) chain A residue 159 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC1 2) chain A residue 162 type sequence D description BINDING SITE FOR RESIDUE ZN A 900 source : AC1 3) chain A residue 176 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC1 4) chain A residue 179 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC1 5) chain D residue 159 type sequence C description BINDING SITE FOR RESIDUE ZN D 900 source : AC3 6) chain D residue 162 type sequence D description BINDING SITE FOR RESIDUE ZN D 900 source : AC3 7) chain D residue 176 type sequence C description BINDING SITE FOR RESIDUE ZN D 900 source : AC3 8) chain D residue 179 type sequence C description BINDING SITE FOR RESIDUE ZN D 900 source : AC3 9) chain A residue 40 type sequence M description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 10) chain A residue 41 type sequence L description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 11) chain A residue 42 type sequence P description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 12) chain A residue 43 type sequence Y description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 13) chain A residue 49 type sequence H description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 14) chain A residue 51 type sequence G description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 15) chain A residue 52 type sequence H description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 16) chain A residue 55 type sequence N description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 17) chain A residue 56 type sequence Y description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 18) chain A residue 529 type sequence G description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 19) chain A residue 530 type sequence G description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 20) chain A residue 532 type sequence E description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 21) chain A residue 533 type sequence H description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 22) chain A residue 566 type sequence Q description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 23) chain A residue 568 type sequence M description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 24) chain A residue 569 type sequence V description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 25) chain A residue 620 type sequence M description BINDING SITE FOR RESIDUE LMS A 901 source : AC5 26) chain D residue 40 type sequence M description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 27) chain D residue 41 type sequence L description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 28) chain D residue 42 type sequence P description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 29) chain D residue 43 type sequence Y description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 30) chain D residue 49 type sequence H description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 31) chain D residue 51 type sequence G description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 32) chain D residue 52 type sequence H description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 33) chain D residue 55 type sequence N description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 34) chain D residue 56 type sequence Y description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 35) chain D residue 529 type sequence G description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 36) chain D residue 530 type sequence G description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 37) chain D residue 532 type sequence E description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 38) chain D residue 533 type sequence H description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 39) chain D residue 566 type sequence Q description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 40) chain D residue 568 type sequence M description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 41) chain D residue 569 type sequence V description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 42) chain D residue 620 type sequence M description BINDING SITE FOR RESIDUE LMS D 901 source : AC6 43) chain A residue 41 type sequence L description BINDING SITE FOR RESIDUE LEU A 902 source : AC7 44) chain A residue 80 type sequence D description BINDING SITE FOR RESIDUE LEU A 902 source : AC7 45) chain A residue 533 type sequence H description BINDING SITE FOR RESIDUE LEU A 902 source : AC7 46) chain A residue 537 type sequence H description BINDING SITE FOR RESIDUE LEU A 902 source : AC7 47) chain D residue 41 type sequence L description BINDING SITE FOR RESIDUE LEU D 902 source : AC8 48) chain D residue 80 type sequence D description BINDING SITE FOR RESIDUE LEU D 902 source : AC8 49) chain D residue 533 type sequence H description BINDING SITE FOR RESIDUE LEU D 902 source : AC8 50) chain D residue 537 type sequence H description BINDING SITE FOR RESIDUE LEU D 902 source : AC8 51) chain A residue 42-53 type prosite sequence PYPSGRLHMGHV description AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PypSGrLHMGHV source prosite : PS00178 52) chain A residue 622 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00049 source Swiss-Prot : SWS_FT_FI1 53) chain D residue 622 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00049 source Swiss-Prot : SWS_FT_FI1

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