eF-site ID 3s2k-ABC PDB Code 3s2k Chain A, B, C click to enlarge Title Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Classification SIGNALING PROTEIN Compound Low-density lipoprotein receptor-related protein 6 Source (DKK1_HUMAN) Sequence A:  PEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDF DVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEG MAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDS PRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPN VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIA DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTII QGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPV GGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMI RKAQEDGSQGFTVVVSEIQPYDLSIDIYSRYIYWTCEATN VINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNL QERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKL FWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW LYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKE LNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVL LQDELSCGEP B:  ADPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASAL DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDL DSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREV IADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRT IIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAV PVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRM VIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQN MIRKAQEDGSQGFTVVVSEIQPYDLSIDIYSRYIYWTCEA TNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFT NLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLG KLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFE NWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAV KELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHL VLLQDELSCGEP C:  KGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCT KHRRKGSHGLEIFQRCYCGEGLSCRIQKRLHTCQRH Description (1)  Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1 Functional site 1) chain B residue 1039 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 859 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 865 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 926 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 1039 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 692 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 7) chain B residue 859 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 865 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1 9) chain B residue 926 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521 source Swiss-Prot : SWS_FT_FI1

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