eF-site ID 3new-A PDB Code 3new Chain A click to enlarge Title p38-alpha complexed with Compound 10 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Mitogen-activated protein kinase 14 Source Homo sapiens (Human) (MK14_HUMAN) Sequence A:  RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCLTDDH VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKI LDFGLATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT AAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWK SLTYDEVISFVPPP Description Functional site 1) chain A residue 191 type sequence P description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 2) chain A residue 192 type sequence E description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 3) chain A residue 195 type sequence L description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 4) chain A residue 197 type sequence W description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 5) chain A residue 246 type sequence L description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 6) chain A residue 249 type sequence K description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 7) chain A residue 250 type sequence I description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 8) chain A residue 251 type sequence S description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 9) chain A residue 252 type sequence S description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 10) chain A residue 259 type sequence I description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 11) chain A residue 291 type sequence L description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 12) chain A residue 336 type sequence E description BINDING SITE FOR RESIDUE 3NE A 361 source : AC1 13) chain A residue 30-54 type prosite sequence VGSGAYGSVCAAFDTKTGLRVAVKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK source prosite : PS00107 14) chain A residue 59-162 type prosite sequence FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE FNDVYLVTHLMGADLNNIVKCLTDDHVQFLIYQILRGLKY IHSADIIHRDLKPSNLAVNEDS description MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedS source prosite : PS01351 15) chain A residue 168 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 16) chain A residue 30 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 17) chain A residue 53 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 18) chain A residue 16 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 53 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 20) chain A residue 152 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 21) chain A residue 263 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI8 22) chain A residue 323 type MOD_RES sequence Y description Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648 source Swiss-Prot : SWS_FT_FI9

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