eF-site ID 3my0-S PDB Code 3my0 Chain S click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence S:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSQLWLITH YHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIF GTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQG SDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDI WAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDM KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSA RLTALRIKKTLQKI Description Functional site 1) chain S residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN P 600 source : BC7 2) chain S residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 3) chain S residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 4) chain S residue 229 type sequence K description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 5) chain S residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 6) chain S residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 7) chain S residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 8) chain S residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 9) chain S residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 10) chain S residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 11) chain S residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 12) chain S residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 13) chain S residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 14) chain S residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN S 600 source : CC1 15) chain S residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 16) chain S residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain S residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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