3MY0

Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189

Summary for 3MY0

• Entry DOI: 10.2210/pdb3my0/pdb
• Descriptor: Serine/threonine-protein kinase receptor R3, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline (3 entities in total)
• Functional Keywords: protein kinase, serine/threonine-protein kinase receptor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P37023
• Total number of polymer chains: 24
• Total formula weight: 845164.82

Authors

Chaikuad, A.,Alfano, I.,Cooper, C.,Mahajan, P.,Daga, N.,Sanvitale, C.,Fedorov, O.,Petrie, K.,Savitsky, P.,Gileadi, O.,Sethi, R.,Krojer, T.,Muniz, J.R.C.,Pike, A.C.W.,Vollmar, M.,Carpenter, C.P.,Ugochukwu, E.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-05-08, release date: 2010-07-21, Last modification date: 2023-11-01)

• Primary citation: Kerr, G.,Sheldon, H.,Chaikuad, A.,Alfano, I.,von Delft, F.,Bullock, A.N.,Harris, A.L.; A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.; Angiogenesis, 18:209-217, 2015; PubMed: 25557927; DOI: 10.1007/s10456-014-9457-y

Experimental method

X-RAY DIFFRACTION (2.65 Å)