eF-site ID 3my0-Q PDB Code 3my0 Chain Q click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence Q:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW AFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR LTALRIKKTLQKIS Description Functional site 1) chain Q residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 2) chain Q residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 3) chain Q residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 4) chain Q residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 5) chain Q residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 6) chain Q residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 7) chain Q residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 8) chain Q residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 9) chain Q residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 10) chain Q residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 11) chain Q residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 12) chain Q residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 13) chain Q residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 14) chain Q residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 15) chain Q residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 16) chain Q residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain Q residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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