eF-site ID 3my0-N PDB Code 3my0 Chain N click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence N:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQL WLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHL HVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAV MHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESY KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDP SFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWY PNPSARLTALRIKKTLQKIS Description Functional site 1) chain N residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 2) chain N residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 3) chain N residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 4) chain N residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 5) chain N residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 6) chain N residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 7) chain N residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 8) chain N residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 9) chain N residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 10) chain N residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 11) chain N residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 12) chain N residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 13) chain N residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN N 600 source : BC5 14) chain N residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 15) chain N residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain N residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links