eF-site ID 3my0-L PDB Code 3my0 Chain L click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence L:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSTQLWLIT HYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEI FGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQ GSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTD IWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFED MKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPS ARLTALRIKKTLQKIS Description Functional site 1) chain L residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 2) chain L residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 3) chain L residue 229 type sequence K description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 4) chain L residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 5) chain L residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 6) chain L residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 7) chain L residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 8) chain L residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 9) chain L residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 10) chain L residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 11) chain L residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 12) chain L residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 13) chain L residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 14) chain L residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN L 600 source : BC3 15) chain L residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 16) chain L residue 292 type sequence Q description BINDING SITE FOR RESIDUE LDN Q 600 source : BC8 17) chain L residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 18) chain L residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain L residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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