eF-site ID 3my0-C PDB Code 3my0 Chain C click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence C:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQL WLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHL HVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAV MHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESY KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDP SFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWY PNPSARLTALRIKKTLQKI Description Functional site 1) chain C residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 2) chain C residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 3) chain C residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 4) chain C residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 5) chain C residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 6) chain C residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 7) chain C residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 8) chain C residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 9) chain C residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 10) chain C residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 11) chain C residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 12) chain C residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN C 600 source : AC3 13) chain C residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 14) chain C residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain C residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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