eF-site ID 3mls-HIJKLMNOPQRS PDB Code 3mls Chain H, I, J, K, L, M, N, O, P, Q, R, S click to enlarge Title Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope Classification IMMUNE SYSTEM Compound Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain Source ORGANISM_SCIENTIFIC: Homo sapiens; Sequence H:  EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL GTQTYICNVNHKPSNTKVDKKVEPKS I:  EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL GTQTYICNVNHKPSNTKVDKKVEPKS J:  EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL GTQTYICNVNHKPSNTKVDKKVEPKS K:  EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL GTQTYICNVNHKPSNTKVDKKVEP L:  SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS YSCQVTHEGSTVEKTVAPT M:  SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS YSCQVTHEGSTVEKTVAPT N:  SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS YSCQVTHEGSTVEKTVAPT O:  SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS YSCQVTHEGSTVEKTVAPT P:  ACQAFYASSPRKSIHIGACA Q:  ACQAFYASSPRKSIHIGACA R:  ACQAFYASSPRKSIHIGACA S:  ACQAFYASSPRKSIHIGACA Description (1)  Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain, Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab heavy chain, Rationally designed V3 mimotope Functional site 1) chain H residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 2) chain L residue 195-201 type prosite sequence YSCQVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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