3MLS

Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope

Summary for 3MLS

Entry DOI	10.2210/pdb3mls/pdb
Related	3MLR 3MLT 3MLU 3MLV 3MLW 3MLX 3MLY 3MLZ
Descriptor	Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain, Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab heavy chain, Rationally designed V3 mimotope, ... (4 entities in total)
Functional Keywords	human monoclonal antibody, fab, hiv-1, gp120, third variable loop, antibody-antigen interaction, mimotope, immune system
Biological source	Homo sapiens More
Total number of polymer chains	12
Total formula weight	198429.32
Authors	Kong, X.-P. (deposition date: 2010-04-18, release date: 2010-07-14, Last modification date: 2017-11-08)
Primary citation	Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat.Struct.Mol.Biol., 17:955-961, 2010 Cited by PubMed: 20622876 DOI: 10.1038/nsmb.1861 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation