Title
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Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope |
Classification
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IMMUNE SYSTEM |
Compound
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Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain |
Source
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ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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H: |
EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI
PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY
LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI
LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKKVEPKS
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I: |
EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI
PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY
LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI
LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKKVEPKS
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J: |
EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI
PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY
LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI
LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKKVEPKS
|
K: |
EVQLVESGGEVKQPGQSLKISCKSSGYNFLDSWIGWVRQI
PGKGLEWIGIIYPDDSDAHYSPSFEGQVTMSVDKSISTAY
LQWTTLQASDTGKYFCTRLYLFEGAQSSNAFDLWGQGTMI
LVSSGTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKKVEP
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L: |
SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG
QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL
DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK
AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA
DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS
YSCQVTHEGSTVEKTVAPT
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M: |
SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG
QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL
DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK
AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA
DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS
YSCQVTHEGSTVEKTVAPT
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N: |
SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG
QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL
DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK
AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA
DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS
YSCQVTHEGSTVEKTVAPT
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O: |
SYDLTQPPSVSVSPGQTASISCSGDKLDDKYVSWYYQRPG
QSPVLLMYQDFKRPSGIPERLSGSKSGKTATLTISGTQSL
DEGDYYCQAWDASTGVSGGGTKLTVLFGDGTRLTVLGQPK
AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA
DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKS
YSCQVTHEGSTVEKTVAPT
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P: |
ACQAFYASSPRKSIHIGACA
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Q: |
ACQAFYASSPRKSIHIGACA
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R: |
ACQAFYASSPRKSIHIGACA
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S: |
ACQAFYASSPRKSIHIGACA
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Description
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(1) |
Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain, Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab heavy chain, Rationally designed V3 mimotope
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