eF-site ID 3lcb-C PDB Code 3lcb Chain C click to enlarge Title The crystal structure of isocitrate dehydrogenase kinase/phosphatase in complex with its substrate, isocitrate dehydrogenase, from Escherichia coli. Classification TRANSFERASE, HYDROLASE Compound Isocitrate dehydrogenase kinase/phosphatase Source Escherichia coli O157:H7 (strain EC4115 / EHEC) (IDH_ECOLI) Sequence C:  ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDV TPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD VWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYA GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVI ADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG IAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAK LLKCSEFGDAIIENM Description Functional site 1) chain C residue 160 type catalytic sequence Y description 7 source MCSA : MCSA1 2) chain C residue 230 type catalytic sequence K description 7 source MCSA : MCSA1 3) chain C residue 283 type catalytic sequence D description 7 source MCSA : MCSA1 4) chain C residue 307 type catalytic sequence D description 7 source MCSA : MCSA1 5) chain C residue 303-322 type prosite sequence NLNGDYISDALAAQVGGIGI description IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLNGDYiSDalAaqv.GGIGI source prosite : PS00470 6) chain C residue 104 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR source Swiss-Prot : SWS_FT_FI1 7) chain C residue 113 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:2204109, ECO:0000269|PubMed:3112144 source Swiss-Prot : SWS_FT_FI10 8) chain C residue 142 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI11 9) chain C residue 113 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD source Swiss-Prot : SWS_FT_FI2 10) chain C residue 115 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD source Swiss-Prot : SWS_FT_FI2 11) chain C residue 129 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD source Swiss-Prot : SWS_FT_FI2 12) chain C residue 153 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW1, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD source Swiss-Prot : SWS_FT_FI2 13) chain C residue 119 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10623532, ECO:0000269|PubMed:2204109, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1CW7, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:1PB1, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJA, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:5ICD, ECO:0007744|PDB:8ICD source Swiss-Prot : SWS_FT_FI3 14) chain C residue 307 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2204109, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI3, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1GRP, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDC, ECO:0007744|PDB:1P8F, ECO:0007744|PDB:4AJB, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:4AJS, ECO:0007744|PDB:4BNP, ECO:0007744|PDB:8ICD source Swiss-Prot : SWS_FT_FI4 15) chain C residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:1ISO, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:9ICD source Swiss-Prot : SWS_FT_FI5 16) chain C residue 352 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:9ICD source Swiss-Prot : SWS_FT_FI6 17) chain C residue 391 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:1BL5, ECO:0007744|PDB:1HJ6, ECO:0007744|PDB:1IDE, ECO:0007744|PDB:4AJ3, ECO:0007744|PDB:4AJR, ECO:0007744|PDB:9ICD source Swiss-Prot : SWS_FT_FI6 18) chain C residue 395 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11284679, ECO:0000269|PubMed:2682654, ECO:0000269|PubMed:7761851, ECO:0007744|PDB:1AI2, ECO:0007744|PDB:9ICD source Swiss-Prot : SWS_FT_FI7 19) chain C residue 160 type SITE sequence Y description Critical for catalysis => ECO:0000269|PubMed:7761851, ECO:0000269|PubMed:7819221 source Swiss-Prot : SWS_FT_FI8 20) chain C residue 230 type SITE sequence K description Critical for catalysis => ECO:0000269|PubMed:7761851, ECO:0000269|PubMed:7819221 source Swiss-Prot : SWS_FT_FI8 21) chain C residue 100 type MOD_RES sequence K description N6-succinyllysine => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI9 22) chain C residue 242 type MOD_RES sequence K description N6-succinyllysine => ECO:0000269|PubMed:21151122 source Swiss-Prot : SWS_FT_FI9

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