eF-site ID 3lcb-A PDB Code 3lcb Chain A click to enlarge Title The crystal structure of isocitrate dehydrogenase kinase/phosphatase in complex with its substrate, isocitrate dehydrogenase, from Escherichia coli. Classification TRANSFERASE, HYDROLASE Compound Isocitrate dehydrogenase kinase/phosphatase Source Escherichia coli O157:H7 (strain EC4115 / EHEC) (IDH_ECOLI) Sequence A:  GLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAV QQAMKNRIHLYDHHVGLVVEQLRCITNEFLLRVKEHYTRL LPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPR PLAKDFHPDHGWESLLMRVISDLPLRLHWQNKSRDIHYII RHLTETLGPENLSKSHLQVANELFYRNKAAWLVGKLITPS GTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYF MVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTES YREYLVYLQGCNEQFIEAPGIRGMVMLVFTLPGFDRVFKV IKDKFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFEN FVLEKRHISPALMELLLQEAAEKITDLGEQIVIRHLYIER RMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGD MLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPE DELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHA DLFRADYWRALQNRIREGHVEDVYAYRRRQRFSV Description Functional site 1) chain A residue 104 type sequence N description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 2) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 3) chain A residue 113 type sequence H description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 4) chain A residue 116 type sequence L description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 5) chain A residue 291 type sequence K description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 6) chain A residue 294 type sequence K description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 7) chain A residue 295 type sequence T description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 8) chain A residue 298 type sequence Y description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 9) chain A residue 375 type sequence F description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 10) chain A residue 376 type sequence E description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 11) chain A residue 377 type sequence N description BINDING SITE FOR RESIDUE AMP A 1604 source : AC1 12) chain A residue 316 type sequence P description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 13) chain A residue 317 type sequence G description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 14) chain A residue 318 type sequence I description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 15) chain A residue 320 type sequence G description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 16) chain A residue 321 type sequence M description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 17) chain A residue 322 type sequence V description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 18) chain A residue 323 type sequence M description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 19) chain A residue 325 type sequence V description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 20) chain A residue 334 type sequence V description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 21) chain A residue 336 type sequence K description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 22) chain A residue 346 type sequence K description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 23) chain A residue 416 type sequence E description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 24) chain A residue 417 type sequence R description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 25) chain A residue 419 type sequence M description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 26) chain A residue 421 type sequence P description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 27) chain A residue 457 type sequence D description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 28) chain A residue 461 type sequence K description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 29) chain A residue 462 type sequence N description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 30) chain A residue 474 type sequence Y description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 31) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 32) chain A residue 477 type sequence D description BINDING SITE FOR RESIDUE ATP A 1760 source : AC2 33) chain A residue 462 type sequence N description BINDING SITE FOR RESIDUE MG A 579 source : AC3 34) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 579 source : AC3

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