eF-site ID 3eql-D PDB Code 3eql Chain D click to enlarge Title Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin Classification TRANSFERASE Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence D:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG VALYRFASILVVKARVYPFEDDVEVSTGDRVAPGDVLADG GKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAEAIQQL LKELDLEALEKELLEEMKHPSRARRAKARKRLEVVRAFLD SGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDLNDLY RRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDN GRRGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVD YSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEK GIAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNR APTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQ MAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRD IILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALN APIKVAGRETSVGRLKYVFANPDEALLAVAHGIVDLQDVV TVRYMGKRLETSPGRILFARIVAEAVEDEKVAWELIQLDV PQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTFSTT SGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMGFLT DRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPLYVMA QSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRSSFREG LTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVTHE IVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADIEAGL YGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQ EVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGIV AAQSIGEPGTQLTMRTFHTGGVAGAADITQGLPRVIELFE ARRPKAKAVISEIDGVVRIEETEEKLSVFVESEGFSKEYK LPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAV ERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTDP GDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWKPLLMGV TKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKE NVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARKEAVE A Description Functional site 1) chain D residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN D1525 source : AC1 2) chain D residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN D1525 source : AC1 3) chain D residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN D1525 source : AC1 4) chain D residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN D1525 source : AC1 5) chain D residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN D1526 source : AC2 6) chain D residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN D1526 source : AC2 7) chain D residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN D1526 source : AC2 8) chain D residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN D1526 source : AC2 9) chain D residue 610 type sequence K description BINDING SITE FOR RESIDUE MXP D1527 source : AC3 10) chain D residue 611 type sequence Q description BINDING SITE FOR RESIDUE MXP D1527 source : AC3 11) chain D residue 619 type sequence L description BINDING SITE FOR RESIDUE MXP D1527 source : AC3 12) chain D residue 620 type sequence G description BINDING SITE FOR RESIDUE MXP D1527 source : AC3 13) chain D residue 1463 type sequence K description BINDING SITE FOR RESIDUE MXP D1527 source : AC3 14) chain D residue 1466 type sequence V description BINDING SITE FOR RESIDUE MXP D1527 source : AC3 15) chain D residue 1467 type sequence I description BINDING SITE FOR RESIDUE MXP D1527 source : AC3 16) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE MG D1528 source : AC4 17) chain D residue 741 type sequence D description BINDING SITE FOR RESIDUE MG D1528 source : AC4 18) chain D residue 743 type sequence D description BINDING SITE FOR RESIDUE MG D1528 source : AC4 19) chain D residue 1201 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 1204 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 73 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 76 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 739 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 741 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 743 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 1112 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 1194 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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