eF-site ID 3d2r-B PDB Code 3d2r Chain B click to enlarge Title Crystal structure of pyruvate dehydrogenase kinase isoform 4 in complex with ADP Classification TRANSFERASE Compound [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4 Source Homo sapiens (Human) (PDK4_HUMAN) Sequence B:  VPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQ ELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDL VEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGII EYKACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF SDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYL SSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAM RATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPL RIIDRLFSYTYSTAPTPPLAGFGYGLPISRLYAKYFQGDL NLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYDW CI Description Functional site 1) chain B residue 258 type sequence N description BINDING SITE FOR RESIDUE MG B 500 source : AC2 2) chain B residue 258 type sequence N description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 3) chain B residue 261 type sequence R description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 4) chain B residue 262 type sequence A description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 5) chain B residue 293 type sequence D description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 6) chain B residue 306 type sequence L description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 7) chain B residue 311 type sequence Y description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 8) chain B residue 312 type sequence S description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 9) chain B residue 313 type sequence T description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 10) chain B residue 328 type sequence A description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 11) chain B residue 329 type sequence G description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 12) chain B residue 330 type sequence F description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 13) chain B residue 331 type sequence G description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 14) chain B residue 333 type sequence G description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 15) chain B residue 334 type sequence L description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 16) chain B residue 358 type sequence T description BINDING SITE FOR RESIDUE ADP B 501 source : AC4 17) chain B residue 395 type sequence W description BINDING SITE FOR RESIDUE GOL A 502 source : AC5 18) chain B residue 160 type sequence D description BINDING SITE FOR RESIDUE GOL B 502 source : AC6 19) chain B residue 339 type sequence L description BINDING SITE FOR RESIDUE GOL B 502 source : AC6 20) chain B residue 342 type sequence K description BINDING SITE FOR RESIDUE GOL B 502 source : AC6 21) chain B residue 374 type sequence K description BINDING SITE FOR RESIDUE GOL B 502 source : AC6 22) chain B residue 254 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18658136 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 293 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18658136 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 312 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18658136 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 329 type BINDING sequence G description BINDING => ECO:0000269|PubMed:18658136 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 157 type SITE sequence Y description Interaction with the other subunit in the homodimer source Swiss-Prot : SWS_FT_FI2 27) chain B residue 161 type SITE sequence R description Interaction with the other subunit in the homodimer source Swiss-Prot : SWS_FT_FI2 28) chain B residue 395 type SITE sequence W description Interaction with the other subunit in the homodimer source Swiss-Prot : SWS_FT_FI2

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