3D2R

Crystal structure of pyruvate dehydrogenase kinase isoform 4 in complex with ADP

Summary for 3D2R

• Entry DOI: 10.2210/pdb3d2r/pdb
• Related: 2ZKJ
• Descriptor: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: protein-nucleotide complex, homodimer, ghkl superfamily, kinase, carbohydrate metabolism, glucose metabolism, mitochondrion, phosphoprotein, transferase, transit peptide
• Biological source: Homo sapiens
• Cellular location: Mitochondrion matrix: Q16654
• Total number of polymer chains: 2
• Total formula weight: 90637.17

Authors

Kato, M.,Wynn, R.M.,Chuang, L.C.,Tso, S.-C.,Li, J.,Chuang, D.T. (deposition date: 2008-05-08, release date: 2008-08-05, Last modification date: 2023-08-30)

• Primary citation: Wynn, R.M.,Kato, M.,Chuang, J.L.,Tso, S.C.,Li, J.,Chuang, D.T.; Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity.; J.Biol.Chem., 283:25305-25315, 2008; PubMed: 18658136; DOI: 10.1074/jbc.M802249200

Experimental method

X-RAY DIFFRACTION (2.03 Å)