eF-site ID 2w8y-B PDB Code 2w8y Chain B click to enlarge Title RU486 bound to the progesterone receptor in a destabilized agonistic conformation Classification RECEPTOR Compound PROGESTERONE RECEPTOR Source Homo sapiens (Human) (PRGR_HUMAN) Sequence B:  LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLG ERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFG LGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMW QIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFE EMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILA GMVKPLLFHKK Description (1)  PROGESTERONE RECEPTOR Functional site 1) chain B residue 715 type sequence L description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 2) chain B residue 718 type sequence L description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 3) chain B residue 719 type sequence N description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 4) chain B residue 725 type sequence Q description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 5) chain B residue 756 type sequence M description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 6) chain B residue 759 type sequence M description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 7) chain B residue 766 type sequence R description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 8) chain B residue 801 type sequence M description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 9) chain B residue 890 type sequence Y description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 10) chain B residue 891 type sequence C description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 11) chain B residue 765 type sequence W description BINDING SITE FOR RESIDUE EDO B 1934 source : AC3 12) chain B residue 770 type sequence H description BINDING SITE FOR RESIDUE EDO B 1934 source : AC3 13) chain B residue 815 type sequence Q description BINDING SITE FOR RESIDUE EDO B 1934 source : AC3

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